Method and/or system for multicompartment analyte monitoring

• US 8,870,763 B2
• Filed: 02/03/2012
• Issued: 10/28/2014
• Est. Priority Date: 10/26/2011
• Status: Active Grant

• Current Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Minimed Incorporated (Medtronic Plc)
• Inventors: Yang, Ning, Gottlieb, Rebecca K., Nogueira, Keith, Li, Xiaolong, Liang, Bradley, Kannard, Brian T.
• Primary Examiner(s): Natnithithadha, Navin
• Assistant Examiner(s): BERHANU, ETSUB D
• Application Number:
  US13/365,406
• Publication Number:
  US 20130109942A1
• Time in Patent Office: 998 Days
• Field of Search: 600/345, 600/347, 600/365, 604/504
• US Class Current: 600/300
• CPC Class Codes: A61B 5/1451 for interstitial fluid
• CPC Class Codes: A61B 5/14528 invasively
• CPC Class Codes: A61B 5/14532 for measuring glucose, e.g. by tissue impedance measurement
• CPC Class Codes: A61B 5/1473 invasive, e.g. introduced into the body by a catheter A61B5/1482 takes precedence
• CPC Class Codes: A61B 5/14865 invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
• CPC Class Codes: A61B 5/1495 Calibrating or testing of in-vivo probes
• CPC Class Codes: A61B 5/4839 combined with drug delivery
• CPC Class Codes: A61B 5/6849 in combination with a needle set
• CPC Class Codes: A61B 5/7242 using integration
• CPC Class Codes: A61B 5/7275 Determining trends in physiological measurement data; Predicting development of a medical condition based on physiological measurements, e.g. determining a risk factor
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: F04C 2270/0421 Controlled or regulated

Abstract

Subject matter disclosed herein relates to monitoring and/or controlling levels of an analyte in bodily fluid. In particular, estimation of a concentration of the analyte in a first physiological compartment based upon observations of a concentration of the analyte in a second physiological compartment may account for a latency in transporting the analyte between the first and second physiological compartments.

Claims

1. A method at least partially executed by a computing apparatus comprising:

modeling a latency in transportation of an analyte between first and second physiological compartments; and

compensating for the latency in estimating a concentration of the analyte in the first physiological compartment based, at least in part, on one or more measurements of a concentration of the analyte in the second physiological compartment by;

combining over time a difference between a sensor signal value and an offset value to provide an integration result;

combining said integration result with a term based, at least in part, on said modeled latency to provide a combined expression; and

determining said estimated concentration based, at least in part, on a computed rate of change in said combined expression.

2. The method of claim 1, wherein the analyte comprises glucose, the first physiological compartment comprises blood plasma, and the second physiological compartment comprises interstitial fluid.

3. The method of claim 1, wherein said sensor signal value comprises a measured current responsive to the concentration of said analyte in said second physiological compartment.

4. The method of claim 1, wherein the latency is based, at least in part, on a latency of a presence of glucose in a patient'"'"'s interstitial fluid to affect a blood glucose concentration in said patient.

5. The method of claim 4, wherein the latency is defined based, at least in part, on a time for 63% of glucose in said interstitial fluid to be absorbed by the patient'"'"'s blood.

6. An apparatus comprising:

a sensor to generate a signal responsive to a concentration of an analyte in a second physiological compartment; and

a processor configured to;

model a latency in transportation of the analyte between the second physiological compartment and a first physiological compartment; and

compensate for the latency in estimating a concentration of the analyte in the first physiological compartment based, at least in part, on the signal responsive to the concentration of the analyte in the second physiological compartment by;

combining over time a difference between a sensor signal value and an offset value to provide an integration result;

combining said integration result with a term based, at least in part, on said modeled latency to provide a combined expression; and

determining said estimated concentration based, at least in part, on a computed rate of change in said combined expression.

7. The apparatus of claim 6, wherein said sensor signal value comprises a measured current responsive to the concentration of said analyte in said second physiological compartment.

8. The apparatus of claim 6, wherein the analyte comprises glucose, the first physiological compartment comprises blood plasma, and the second physiological compartment comprises interstitial fluid.

9. The apparatus of claim 6, wherein the latency is based, at least in part, on a latency of a presence of glucose in a patient'"'"'s interstitial fluid to affect a blood glucose concentration in said patient.

10. The apparatus of claim 9, wherein the latency is defined based, at least in part, on a time for 63% of glucose in said interstitial fluid to be absorbed by the patient'"'"'s blood.

11. The apparatus of claim 6, the processor configured further to generate a command to one or more infusion pumps computed based, at least in part, on said estimated concentration.

12. An article comprising:

a non-transitory storage medium having machine-readable instructions stored thereon which are executable by a special purpose computing apparatus to;

model a latency in transportation of an analyte between first and second physiological compartments; and

compensate for the latency in estimating a concentration of the analyte in the first physiological compartment based, at least in part, on one or more measurements of a concentration of the analyte in the second physiological compartment by;

combining over time a difference between a sensor signal value and an offset value to provide an integration result;

combining said integration result with a term based, at least in part, on said modeled latency to provide a combined expression; and

determining said estimated concentration based, at least in part, on a computed rate of change in said combined expression.

13. The article of claim 12, wherein the analyte comprises glucose, the first physiological compartment comprises blood plasma, and the second physiological compartment comprises interstitial fluid.

14. The article of claim 12, wherein said sensor signal value comprises a measured current responsive to the concentration of said analyte in said second physiological compartment.

15. An apparatus comprising:

means for modeling a latency in transportation of an analyte between first and second physiological compartments; and

means for compensating for the latency in estimating a concentration of the analyte in the first physiological compartment based, at least in part, on one or more measurements of a concentration of the analyte in the second physiological compartment by;

combining over time a difference between a sensor signal value and an offset value to provide an integration result;

combining said integration result with a term based, at least in part, on said modeled latency to provide a combined expression; and

determining said estimated concentration based, at least in part, on a computed rate of change in said combined expression.