Implantable or insertable medical devices containing silicone copolymer for controlled delivery of therapeutic agent
First Claim
1. An implantable or insertable medical device comprising (a) a therapeutic agent and (b) a polymeric carrier region that comprises said therapeutic agent and which releases said therapeutic agent upon administration to a patient, said polymeric carrier region comprising a silicone block copolymer comprising a plurality of siloxane units and a plurality of non-siloxane units, said block copolymer comprising (i) a block of said siloxane units selected from a polydimethylsiloxane block, a polydiethylsiloxane block, a polymethylethylsiloxane block and a polymethylphenylsiloxane block and (ii) a block of elevated Tg non-siloxane units, wherein the polymeric carrier region is in the form of a coating layer that covers all or a part of said medical device.
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Accused Products
Abstract
Implantable or insertable medical devices are described. The medical devices comprise (a) a therapeutic agent and (b) a polymeric release region, which controls the release of the therapeutic agent upon administration to a patient. The polymeric release region further comprises a silicone copolymer that contains a plurality of siloxane units and a plurality of non-siloxane units. Also described are methods for administering a therapeutic agent to a patient using the above implantable or insertable medical devices as well as methods of making the above devices.
39 Citations
27 Claims
- 1. An implantable or insertable medical device comprising (a) a therapeutic agent and (b) a polymeric carrier region that comprises said therapeutic agent and which releases said therapeutic agent upon administration to a patient, said polymeric carrier region comprising a silicone block copolymer comprising a plurality of siloxane units and a plurality of non-siloxane units, said block copolymer comprising (i) a block of said siloxane units selected from a polydimethylsiloxane block, a polydiethylsiloxane block, a polymethylethylsiloxane block and a polymethylphenylsiloxane block and (ii) a block of elevated Tg non-siloxane units, wherein the polymeric carrier region is in the form of a coating layer that covers all or a part of said medical device.
Specification