Device for conserving, extemporaneously preparing, and administering an active principle
First Claim
1. A device for conserving and extemporaneously preparing a single injectable dose of at least one unstable active principle prior to administration, the device comprising:
- a body made of thick plastic material or glass, said body comprising at least one compartment for containing at least one volume of pharmaceutical solvent that is less than 5 mL;
a head comprising at least one compartment for containing at least one active principle, and, in a top portion of the compartment, by at least one dose-taking chamber provided with a filter separating the compartment for containing the active principle from the dose-taking chamber, said head comprising a sterile perforatable membrane for protecting the dose, said device comprising a removable protective cap held on said head, the head being capable of taking up a first position P1 for conservation, in which said head is in its distal position relative to the body, and a second position P2 for preparation, in which said head is in its proximal position relative to the body;
at least one wall separating the body and the head; and
a perforator for rupturing said wall so that the active principle enters into contact with the solvent and dissolves therein.
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Accused Products
Abstract
The invention provides a device (10) for conserving and extemporaneously preparing at least one active principle prior to administration, the device comprising: a body (12) that is constituted by at least one compartment for containing at least one volume of pharmaceutical solvent (22) that is less than 5 mL; a head (14) constituted by at least one compartment for containing at least one active principle (24), in particular a very small dose, and, in its top portion, by at least one dose-taking chamber (32) provided with a filter (40), the head (14) being capable of taking up a first position P1 for conservation, in which said head (14) is in its distal position relative to the body (12), and a second position P2 for preparation, in which said head (14) is in its proximal position relative to the body (12); at least one wall (16) separating the body (12) and the head (14); and rupture means (18) for rupturing said wall (16) so that the active principle (24) enters into contact with the solvent (22) and dissolves therein. The invention also seeks to use the device for conserving and extemporaneously preparing at least one active principle with a view to administering it.
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Citations
20 Claims
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1. A device for conserving and extemporaneously preparing a single injectable dose of at least one unstable active principle prior to administration, the device comprising:
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a body made of thick plastic material or glass, said body comprising at least one compartment for containing at least one volume of pharmaceutical solvent that is less than 5 mL; a head comprising at least one compartment for containing at least one active principle, and, in a top portion of the compartment, by at least one dose-taking chamber provided with a filter separating the compartment for containing the active principle from the dose-taking chamber, said head comprising a sterile perforatable membrane for protecting the dose, said device comprising a removable protective cap held on said head, the head being capable of taking up a first position P1 for conservation, in which said head is in its distal position relative to the body, and a second position P2 for preparation, in which said head is in its proximal position relative to the body; at least one wall separating the body and the head; and a perforator for rupturing said wall so that the active principle enters into contact with the solvent and dissolves therein. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 17, 18)
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16. The method of chain 14, wherein the preparing of the at least one active principle comprises combining the at least one active principle with a anti-angiogenic active principle.
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19. A device for conserving and extemporaneously preparing a single injectable dose of at least one unstable active principle prior to administration, the device comprising:
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a body, the body having a compartment containing at least one volume of pharmaceutical solvent; a head having a compartment containing at least one active principle and a dose-taking chamber provided with a filter between the compartment containing the active principle from the dose taking chamber, the head having a membrane that protects the dose and configured to be perforated by a needle carried by syringe while maintaining a seal around the needle; a removable protective cap held on the head, the head configured to take up a first position P1 for conservation, in which the head is in a distal position relative to the body, and a second position P2 for preparation, in which the head is in a proximal position relative to the body; at least one wall separating the body and the head; and a perforator configured to rupture the wall so that the active principle enters into contact with the solvent and dissolves therein to thereby form the injectable dose of unstable active principle that is removable by the syringe and needle perforated through the membrane. - View Dependent Claims (20)
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Specification