Devices for detecting analytes in fluid sample

• US 8,871,155 B2
• Filed: 11/13/2006
• Issued: 10/28/2014
• Est. Priority Date: 11/30/2005
• Status: Active Grant

• Current Assignee: Alere Switzerland GmbH (Abbott Laboratories Incorporated)
• Original Assignee: Alere Switzerland GmbH (Abbott Laboratories Incorporated)
• Inventors: Wu, Yuzhang, Ling, Yun, Dai, Jielin
• Primary Examiner(s): SIEFKE, SAMUEL P
• Application Number:
  US12/095,325
• Publication Number:
  US 20090226883A1
• Time in Patent Office: 2,906 Days
• Field of Search: 422/56, 422/58, 422/102, 422/400, 422/401, 422/402, 422/403, 422/68.1, 422/501, 436/165
• US Class Current: 422/401
• CPC Class Codes: B01L 2200/027 for microfluidic devices
• CPC Class Codes: B01L 2300/0663 Whole sensors
• CPC Class Codes: B01L 3/5023 with a sample being transported to, and subsequently stored in an absorbent for analysis
• CPC Class Codes: B01L 3/5029 using swabs
• CPC Class Codes: G01N 2035/00108 Test strips, e.g. paper

Abstract

A device for detecting the presence or amount of an analyte in a fluid sample and method thereof, comprises a sample collector and a receiving cup for receiving and holding the sample collector within the receiving cup. The sample collector contains a compressible absorbent member for collecting the fluid sample, and has a first position and a second, locked position within the receiving cup. The absorbent member is uncompressed in the first position and is compressed in the second, locked position. The sample collector or the receiving cup has at least one test element having reagents for detecting the presence or amount of the analyte in the fluid sample.

Claims

1. A device for detecting the presence or amount of an analyte in a fluid sample comprising:

a sample collector comprising a compressible absorbent member for collecting the fluid sample, at least one test element having reagents for detecting the presence or amount of the analyte in the fluid sample, and an extender element positioned between the absorbent member and the test element and defining an elongated fluid passageway between the absorbent member and the test element; and

a receiving cup reversibly coupled to the sample collector for receiving and holding the sample collector within the receiving cup, the receiving cup having a sidewall, a first open end for engaging the sample collector, a second end opposing the first open end, and a sampling hole through the wall separate from the open end, the sample collector having a first position and a second, locked position within the receiving cup, the compressible absorbent member being uncompressed in the first position and being compressed and held within the cup in the second, locked position, and wherein transition from the first position to the second position causes extraction of the fluid sample from the compressible absorbent member and flow of a portion of the fluid sample along the elongated fluid passageway to the test element via a compressive force generated between the extender element and the second end of the receiving cup.

2. The device of claim 1 wherein the sample collector comprises a test element holder housing the test element.

3. The device of claim 1 wherein an absorbent pad is positioned between the extender element and the test element and transfers fluid from the passageway to the test element.

4. The device of claim 1 wherein the sample collector comprises circumferential screw threads, and the receiving cup comprises circumferential receiving threads.

5. The device of claim 4 wherein the screw threads and receiving threads are engaged when the sample collector is in the second, locked position.

6. The device of claim 5 wherein the receiving cup is sealed from fluid communication with the exterior when the sample collector is in the second, locked position.

7. The device of claim 1 wherein the sample collector and the receiving cup are joined by a snap fit connection when the sample collector is in the second, locked position.

8. The device of claim 1 wherein the absorbent member is a sponge suitable for placing in the mouth of a test subject, and the fluid sample is saliva.

9. The device of claim 2 wherein the sample collector comprises a flattened handle for manually gripping the sample collector.