Recombinant vectors based on the modified vaccinia ankara virus (MVA) as preventive and therapeutic vaccines against AIDS
First Claim
1. A recombinant modified Vaccinia Ankara (MVA) vector comprising nucleotide sequences encoding a modified human immunodeficiency type 1 virus (HIV-1) Env protein and a HIV-1 Gag-Pol-Nef fusion protein, wherein the nucleotide sequence encoding the modified HIV-1 Env protein is SEQ ID NO:
- 15 or SEQ ID NO;
17, wherein the nucleotide sequence encoding the Env protein and the nucleotide sequence encoding the Gag-Pol-Nef fusion protein are under the control of identical promoters and are both inserted at the thymidine kinase locus of the vector so that the recombinant vector lacks the thymidine kinase gene.
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Abstract
Recombinant vectors which are based on the Modified Ankara Virus (MVA) as preventive and therapeutic vaccines against AIDS. The recombinant viruses contain sequences which are inserted at an MVA insertion site and enable simultaneous expression of antigens, a HIV-1 Env protein consisting of a gp120 protein lacking sequences corresponding to protein gp 41 and a chimeric fusion protein of Gag, Pol and Nef. These viruses are stable and can trigger immune responses against a large variety of antigens. Viruses having a chimeric protein from HIV-1 are suitable for the preparation of vaccines against AIDS.
10 Citations
35 Claims
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1. A recombinant modified Vaccinia Ankara (MVA) vector comprising nucleotide sequences encoding a modified human immunodeficiency type 1 virus (HIV-1) Env protein and a HIV-1 Gag-Pol-Nef fusion protein, wherein the nucleotide sequence encoding the modified HIV-1 Env protein is SEQ ID NO:
- 15 or SEQ ID NO;
17, wherein the nucleotide sequence encoding the Env protein and the nucleotide sequence encoding the Gag-Pol-Nef fusion protein are under the control of identical promoters and are both inserted at the thymidine kinase locus of the vector so that the recombinant vector lacks the thymidine kinase gene. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
- 15 or SEQ ID NO;
Specification