Hydrophilic coating

• US 8,871,869 B2
• Filed: 12/11/2006
• Issued: 10/28/2014
• Est. Priority Date: 12/09/2005
• Status: Active Grant

• Current Assignee: DSM IP Assets BV (DSM-Firmenich AG)
• Original Assignee: DSM IP Assets BV (DSM-Firmenich AG)
• Inventors: Dias, Aylvin Jorge Angelo Athanasius, Hensen, Guido Joseph Elisabeth, Belt, Johannes Wilhelmus, Rooijmans, Marnix, Currie, Edwin Peter Kennedy, de Bont, Nicolaes Hubertus Maria
• Primary Examiner(s): RIOJA, MELISSA A
• Application Number:
  US12/096,096
• Publication Number:
  US 20080292776A1
• Time in Patent Office: 2,878 Days
• Field of Search: 427/2, 427/2.31, 427/2.1, 427/2.3, 427/2.25, 525/218
• US Class Current: 525/218
• CPC Class Codes: A61L 29/085 Macromolecular materials
• CPC Class Codes: C08J 7/0427 with only one layer of a composition containing a polymer binder with more layers C08J7/042
• CPC Class Codes: C08J 7/043 Improving the adhesiveness of the coatings per se, e.g. forming primers adhesives in the form of films or foils characterised by the primer layers between the polymer carriers and the adhesives C09J7/50
• CPC Class Codes: C08J 7/046 Forming abrasion-resistant coatings; Forming surface-hardening coatings
• CPC Class Codes: C08J 7/056 Forming hydrophilic coatings
• CPC Class Codes: C08L 39/06 Homopolymers or copolymers of N-vinyl-pyrrolidones
• CPC Class Codes: C08L 71/02 Polyalkylene oxides
• CPC Class Codes: C09D 5/00 Coating compositions, e.g. paints, varnishes or lacquers, characterised by their physical nature or the effects produced electrically insulating plastics, resins or waxes H01B3/30; Filling pastes
• CPC Class Codes: Y10T 428/264 Up to 3 mils
• CPC Class Codes: Y10T 428/31504 Composite [nonstructural laminate]
• CPC Class Codes: Y10T 428/31533 Of polythioether

Abstract

The invention relates to a hydrophilic coating formulation which when cured results in a hydrophilic coating, wherein the hydrophilic coating formulation comprises a polyelectrolyte and a non-ionic hydrophilic polymer. The invention further relates to a coating system, a hydrophilic coating, a lubricious coating, use of a polyelectrolyte and a non-ionic hydrophilic polymer in a lubricious coating, an article, a medical device or component and a method of forming on a substrate a hydrophilic coating.

Claims

1. A hydrophilic coating formulation which when cured results in a hydrophilic coating, wherein the hydrophilic coating formulation comprises, based on the total dry weight of the hydrophilic coating formulation:

5-30 wt. % of a polyelectrolyte selected from the group consisting of poly(acrylamide-co-acrylic acid) salts, a poly(methacrylamide-co-acrylic acid) salts, a poly(acrylamide-co-methacrylic acid) salts, poly(methacrylamide-co-methacrylic acid) salts, a poly(acrylamide-co-maleic acid) salts, poly(methacrylamide-co-maleic acid) salts, poly(acrylamide-co-dialkylammoniumchloride) and poly(methacrylamide-co-dialkylammoniumchloride),

at least 30 wt. % of a non-ionic hydrophilic polymer,

a free-radical photoinitiator, and

a plasticizer in an amount of from about 0.01 wt. % to about 15 wt. %.

2. The hydrophilic coating formulation according to claim 1, wherein the non-ionic hydrophilic polymer is selected from the group consisting of poly(lactams), polyurethanes, homo- and copolymers of acrylic and methacrylic acid, polyvinyl alcohol, polyvinylethers, maleic anhydride based copolymers, polyesters, vinylamines, polyethyleneimines, polyethyleneoxides, poly(carboxylic acids), polyamides, polyanhydrides, polyphosphazenes, cellulosics, heparin, dextran, polypeptides, and polysacharrides.

3. The hydrophilic coating formulation according to claim 1, the hydrophilic coating formulation further comprising a supporting monomer and/or polymer, which comprises a plurality of reactive moieties capable of undergoing cross-linking reactions.

4. The hydrophilic coating formulation according to claim 3, wherein the supporting monomer and/or polymer is a hydrophilic supporting monomer and/or polymer.

5. The hydrophilic coating formulation according to claim 1, the hydrophilic coating formulation further comprising at least one surfactant.

6. A hydrophilic coating obtained by curing the coating formulation according to claim 1.

7. A lubricious coating obtained by applying a wetting fluid to the hydrophilic coating according to claim 6.

8. The lubricious coating according to claim 7 having an initial lubricity after 1 cycle as measured on a Harland FTS Friction Tester of 20 g or less.

9. A coating system for preparing a lubricious coating, said coating system comprising the hydrophilic coating formulation according to claim 1 and a wetting fluid comprising a polyelectrolyte.

10. An article comprising at least one hydrophilic coating according to claim 6.

11. An article according to claim 10, wherein the article is a medical device or component.

12. An article according to claim 11, wherein the medical device or component comprises a catheter, a medical tubing, a guidewire, a stent, or a membrane.

13. A method of forming on a substrate a hydrophilic coating, the method comprising applying a hydrophilic coating formulation according to claim 1 to at least one surface of the article;

and allowing the coating formulation to cure by exposing the formulation to electromagnetic radiation thereby activating the free-radical photoinitiator.

14. An article comprising at least one lubricious coating according to claim 11 or 13.

15. The hydrophilic coating formulation according to claim 1, wherein the plasticizer is present in an amount of from about 1 wt. % to about 5 wt. %.

16. The hydrophilic coating formulation according to claim 1, wherein the plasticizer has a boiling point at atmospheric pressure of greater than 200°

C.

17. The hydrophilic coating formulation according to claim 1, wherein the plasticizer is selected from the group consisting of mono-alcohols, polyalcohols and polyethers.

18. The hydrophilic coating formulation according to claim 1, wherein the plasticizer is selected from the group consisting of decanol, glycerol, ethylene glycol, diethylene glycol, polyethylene glycol, copolymers with propylene glycol, and fatty acids.

19. A hydrophilic coating obtained by curing the hydrophilic coating formulation according to claim 18.

20. An article comprising the hydrophilic coating according to claim 19, wherein the article is a medical device or component.