Method for determining electrical biopotentials

• US 8,874,185 B2
• Filed: 11/30/2012
• Issued: 10/28/2014
• Est. Priority Date: 06/22/2005
• Status: Active Grant

• Current Assignee: Ambu A/S (AMBU)
• Original Assignee: Ambu A/S (AMBU)
• Inventors: Sonnenborg, Finn Albert
• Primary Examiner(s): Dvorak, Linda
• Assistant Examiner(s): ANTISKAY, BRIAN MICHAEL
• Application Number:
  US13/690,553
• Publication Number:
  US 20130131481A1
• Time in Patent Office: 697 Days
• Field of Search: 600/372, 600/374, 600/382, 600/384, 600/386, 600/391, 600/393, 600395-396, 600508-509
• US Class Current: 600/382
• CPC Class Codes: A61B 2560/0412 Low-profile patch shaped housings
• CPC Class Codes: A61B 5/0006 ECG or EEG signals
• CPC Class Codes: A61B 5/24 Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
• CPC Class Codes: A61B 5/282 Holders for multiple electrodes for introduction into the body A61B5/287
• CPC Class Codes: A61B 5/327 Generation of artificial ECG signals based on measured signals, e.g. to compensate for missing leads

Abstract

A set of electrodes suitable for being attached to the skin of an animal or human being at locations normally used for attaching single-lead electrodes with a single sensor point. The electrodes of the set of electrodes have at least three sensors arranged to define two linearly independent directions, which allows sensing corresponding electrical potential differences in the two directions. Signals representing sensed potential differences can be transmitted wirelessly or via conductors to a processing apparatus for being transformed into electrical potentials that approximate traditional potentials obtained with wired single-sensor electrodes. A method is also presented.

Claims

1. A method of determining the electrical potential of a first location (A) on skin of an animal or human being relative to a reference location (R) on the skin of an animal or human being, the method comprising the steps of:

attaching, to each of the first location (A) and the reference location (R) an electrode, each electrode having at least three sensors arranged so that lines through centers of respective pairs of sensors define two linearly independent directions, and where the electrode attached at the first location and the electrode attached at the reference location are oriented such that the two linearly independent directions defined by the electrode at the first location (A) are substantially the same as the two linearly independent directions of the electrode at the reference location (R), each electrode being connected to a wireless transmitter that is adapted to receive sensed electrical potential and to transmit signals representing the sensed electrical potentials;

sensing, with each of the sensors on each electrode;

an electrical potential on the skin;

transmitting, using each respective wireless transmitter, signals representing at least two differences between pairs of potentials sensed with corresponding pairs of sensors on each electrode;

receiving, using a wireless receiver, the transmitted signals; and

determining the electrical potential at the first location (A) relative to the reference location (R) based on the received signals.

2. A method according to claim 1 further comprising determining parameters representing an instantaneous amplitude of a bioelectrical field in the animal or human being.

3. A method according to claim 1 further comprising determining parameters representing a polarity of a bioelectrical field in the animal or human being.

4. A method according to claim 1 further comprising determining parameters representing a direction of propagation of a bioelectrical field in the animal or human being.

5. A method of determining electrical potential at a first location (A) relative to a reference location (R) on skin of an animal or human being, the method comprising.

attaching to each of the first (A) and reference (R) locations an electrode having at least three sensors arranged so that lines through centers of respective pairs of sensors define two linearly independent directions, such that the electrode attached at the first location and the electrode attached at the reference location are oriented such that the two linearly independent directions defined by the electrode at the first location (A) are substantially the same as the two linearly independent directions of the electrode at the reference location (R), the electrode attached at the first location and the electrode attached at the reference location being connected to a first wireless transmitter and a second wireless transmitter, respectively, that are adapted to receive sensed electrical potential and to transmit signals associated with the sensed electrical potentials;

at the first location (A);

sensing an electrical potential (VA_r) in a first reference position,

sensing an electrical potential (VA_dirX) in a position in a first direction from the first reference position,

determining, using the first wireless transmitter, a first electrical potential difference (VA_dirX)−

(VA_r) between the electrical potential (VA_dirX) in the position in the first direction from the first reference position and the electrical potential (VA_r) in the first reference position,

sensing an electrical potential (VA_dirY) in a position in a second direction from the first reference position,

determining, using the first wireless transmitter, a second electrical potential difference (VA_dirY)−

(VA_r) between the electrical potential (VA_dirY) in the second direction from the first reference position and the electrical potential (VA_r) in the first reference position,

transmitting, using the first wireless transmitter, signals representing the first and second electrical potential difference;

at the reference location (R);

sensing an electrical potential (VR_r) in a second reference position,

sensing an electrical potential (VR_dirX) in a position in a third direction from the second reference position,

determining, using the second wireless transmitter, a third electrical potential difference (VR_dirX)−

(VR_r) between the electrical potential (VR_dirX) in the third direction from the second reference position and the electrical potential (VR_r) in the second reference position,

sensing an electrical potential (VR_dirY) in a position in a fourth direction from the second reference position,

determining, using the second wireless transmitter, a fourth electrical potential difference (VR_dirY)−

(VR_r) between the electrical potential (VR_dirY) in the fourth direction from the second reference position and the electrical potential (VR_r) in the second reference position,

transmitting, using the second wireless transmitter, signals representing the third and fourth electrical potential difference,

receiving, using a wireless receiver, the transmitted signals, and

determining the electrical potential of the first location (A) relative to the reference location (R) based on the first, second, third and fourth electrical potential differences.

6. A method according to claim 5 wherein the electrical potential of the first location (A) relative to the reference location (R) is based on a difference between a size of a first vector defined by instantaneous first and second electrical potential differences and a size of a reference vector defined by instantaneous third and fourth electrical potential differences.

7. A method according to claim 5 wherein the electrical potential of the first location (A) relative to the reference location (R) is based on a difference between a size of a first vector defined by integrated first and second electrical potential differences and a size of a reference vector defined by integrated third and fourth electrical potential differences.

8. A method according to claim 5 wherein the electrical potential of the first location (A) relative to the reference location (R) is based on a difference between a time integrated magnitude of a first vector defined by the first and second electrical potential differences and a time integrated magnitude of a reference vector defined by the third and fourth electrical potential differences.

9. A method according to claim 5, characterized in that the electrical potential of the first location (A) relative to the reference location (R) is determined as a sum of

a first difference between the first electrical potential difference and the third electrical potential difference and

a second difference between the second electrical potential difference and the fourth electrical potential difference.

10. A method according to claim 5, characterized in that the electrical potential of the first location (A) relative to the reference location (R) is determined as a sum of

a first difference between an integration of the first electrical potential difference and an integration of the third electrical potential difference and

a second difference between an integration of the second electrical potential difference and an integration of the fourth electrical potential difference.

11. A method according to claim 5, characterized in that the electrical potential of the first location (A) relative to the reference location (R) is determined as a sum of

a first difference between a moving average of the first electrical potential difference and a moving average of the third electrical potential difference and

a second difference between a moving average of the second electrical potential difference and a moving average of the fourth electrical potential difference.