Arrangement and method for influencing and/or detecting magnetic particles

• US 8,874,188 B2
• Filed: 12/10/2009
• Issued: 10/28/2014
• Est. Priority Date: 12/17/2008
• Status: Expired due to Fees

• Current Assignee: Koninklijke Philips Electronics N.V. (Koninklijke Philips N.V.)
• Original Assignee: Koninklijke Philips N.V.
• Inventors: Gleich, Bernhard
• Primary Examiner(s): Le, Long V.
• Assistant Examiner(s): LARYEA, LAWRENCE N
• Application Number:
  US13/139,380
• Publication Number:
  US 20110241663A1
• Time in Patent Office: 1,783 Days
• Field of Search: 600407-409, 600/420, 600422-425, 324/204, 324/228, 324/307, 324/318, 607/105, 73/530.1, 702/57, 328/204, 328/228, 328/307, 328/309, 328/318, 307104-105, 307/401, 363 39- 44
• US Class Current: 600/409
• CPC Class Codes: A61B 5/05 Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves impedance plethysmography A61B5/0295; measuring movement of the entire body or parts thereof A61B5/11; detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof A61B5/24
• CPC Class Codes: A61B 5/0515 Magnetic particle imaging
• CPC Class Codes: H03F 3/005 using switched capacitors, e.g. dynamic amplifiers; using switched capacitors as resistors in differential amplifiers H03F3/45 takes precedence

Abstract

An arrangement and a corresponding method for influencing and/or detecting magnetic particles in a region of action include storing required reactive energy in a tank circuit, which is preferably operating at the center frequency of a magnetic particle imaging (MPI) drive field. Reactive elements, such as capacitors and/or inductors, couple one or more tank circuits to the drive field resonator. The coupling strength maybe varied by switching additional reactive elements into and out of the coupling unit to vary the strength of coupling.

Claims

1. An arrangement for at least one of influencing and detecting magnetic particles in a region of action, wherein the arrangement comprises:

a selector configured to generate a magnetic selection field having a pattern in space of a magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action;

a driver configured to change a position in space of the two sub-zones in the region of action by a magnetic drive field so that magnetization of the magnetic particles changes locally, said driver comprising drive field coil units;

a receiver configured to acquire detection signals, wherein the detection signals depend on the magnetization in the region of action, wherein the magnetization is influenced by a change in the position in space of the two sub-zones, drive field generator units for generating drive signals for said drive field coil units;

drive signal amplifiers configured to amplify said drive signals;

a coupler coupled between said drive signal amplifiers and said drive field coil units, said coupler comprising at least one tank circuit coupled to an output of said drive field amplifiers and a reactive coupling unit coupled between an output of said at least one tank circuit and an input of the respective drive field coil unit, wherein said at least one tank circuit comprises a capacitor and an inductor connected in parallel and at least one switched reactive element;

at least one switch connected in series with the at least one switched reactive element to form a series connection, and configured to connect and disconnect the at least one switched reactive element from the parallel connected capacitor and the inductor, wherein the parallel connected capacitor and inductor are further connected in parallel with the series connection of the at least one switch and the at leapt one switched reactive element; and

a controller configured to operate said at least one tank circuit at a variable operating frequency by opening and closing the at least one switch to connect and disconnect the at least one switched reactive element from the parallel connected capacitor and the inductor.

2. The arrangement as claimed n claim 1,

wherein said variable operating frequency is an order of a bandwidth of the magnetic drive field.

3. The arrangement as claimed in claim 1,

wherein said variable operating frequency is in a frequency range from 0 to 5 kHz.

4. The arrangement as claimed in claim 1,

wherein said coupler comprises two or more reactive coupling elements and switches configured to switch at least one of said two or more reactive coupling element in and out of a signal path to vary a strength of the coupling.

5. The arrangement as claimed in claim 1,

wherein said at least one tank circuit of said coupler comprises a first tank circuit and a second tank circuit coupled in parallel to the first tank circuit.

6. The arrangement as claimed in claim 1,

wherein said controller is further configured to control the variable operating frequency dependent on changes of the magnetic drive field or of the position in space of the two sub-zones.

7. The arrangement as claimed in claim 6,

wherein said controller is further configured to control the variable operating frequency such that a switching pulse is generated when the first sub-zone is at or near an edge of the region of action.

8. The arrangement of claim 1, wherein said variable operating frequency is in a frequency range from 0 to 2 kHz.

9. A method for influencing and/or detecting magnetic particles in a region of action, wherein the method comprises the acts of:

generating a magnetic selection field having a pattern in space of a magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in the region of action;

changing a position space of the two sub-zones in the region of action by a driver configured to generate a magnetic drive field as that a magnetization of the magnetic particles changes locally, said driver comprising drive field coil units;

acquiring detection signals, wherein the detection signals depend on the magnetization in the region of action, wherein the magnetization is influenced by a change in the position in space of the two sub-zones;

generating drive signals for said drive field coil units;

amplifying said drive signals;

coupling said amplified drive signals to said drive field coil units by a coupler comprising at least one tank circuit coupled to an output of said drive field amplifiers and a reactive coupling unit coupled between an output of said at least one tank circuit and an input of a respective drive field coil unit, wherein said at least one tank circuit comprises a capacitor and an inductor connected in parallel and at least one switched reactive element; and

operating said at least one tank circuit at a variable operating frequency by opening and closing at least one switch connected in series with the at least one switched reactive element to form a series connection, and to connect and disconnect the at least one switched reactive element from the parallel connected capacitor and the inductor, wherein the parallel connected capacitor and inductor are further connected in parallel with the series connection of the at least one switch and the at least one switched reactive element.

10. A non-transitory computer readable medium comprising computer instructions which, when executed by a processor, configure the processor to perform the acts of:

generating a magnetic selection field having a pattern in space of a magnetic field strength such that a first sub-zone having a low magnetic field strength and a second sub-zone having a higher magnetic field strength are formed in a region of action;

changing a position in space of the two sub-zones in the region of action by a driver configured to generate a magnetic drive field so that a magnetization of the magnetic particles changes locally, said driver comprising drive field coil units;

acquiring detection signals, wherein the detection signals depend on the magnetization in the region of action, wherein the magnetization is influenced by a change in the position in space of the two sub-zones;

generating drive signals for said drive field coil units;

amplifying said drive signals;

coupling said amplified drive signals to said drive field coil units by coupler comprising at least one tank circuit coupled to an output of said drive field amplifiers and a reactive coupling unit coupled between an output of said at least one tank circuit and an input of a respective drive field coil unit, wherein said at least one tank circuit comprises a capacitor and an inductor connected in parallel and at least one switched reactive element; and

operating said at least one tank circuit at a variable operating frequency by opening and closing at least one switch connected in series with the at least one switched reactive element to form a series connection, and to connect and disconnect the at least one switched reactive element from the parallel connected capacitor and the inductor, wherein the parallel connected capacitor and inductor are further connected in parallel with the series connection of the at least one switch and the at least one switched reactive element.