Nasal administration
First Claim
1. A nasal delivery device for delivering g powdered sumatriptan substance to a nasal cavity of a human subject, the delivery device comprising:
- a nosepiece for fitting to the nasal cavity of the subject, anda capsule-containing member which contains a capsule, the capsule containing the powdered sumatriptan substance to be delivered to the nasal cavity of the subject,wherein the capsule-containing member includes a flow passage in which the capsule is disposed to be rotatable therewithin when an air flow is delivered therethrough, the flow passage including an inlet and an outlet which is in fluid communication with the nosepiece,wherein the device is configured such that, when the nosepiece is fitted to the nasal cavity of the subject, oral exhalation by the subject through the nosepiece acts to close the velum of the subject and drive an air flow through the nasal cavity, with the air flow passing into one nasal passage and out the other nasal passage, thereby achieving a bi-directional air flow, andwherein the powdered sumatriptan substance has a particle size distribution of 10% less than about 20 μ
m, 50% less than about 50 μ
m and 90% less than about 150 μ
m.
5 Assignments
0 Petitions
Accused Products
Abstract
A delivery device for and method of delivering a powdered substance, in particular a triptan, such as sumatriptan, to the posterior region of a nasal cavity of a subject, in particular for the treatment of headaches, for example, cluster headaches and migraine, and neuropathic pain, the delivery device comprising: a nosepiece for insertion into a nasal cavity of a subject through which the powdered substance is delivered to the posterior region of the nasal cavity of the subject, in particular the upper posterior two thirds of the nasal cavity; and a substance supply unit which is operable to deliver the powdered substance through the nosepiece.
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Citations
20 Claims
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1. A nasal delivery device for delivering g powdered sumatriptan substance to a nasal cavity of a human subject, the delivery device comprising:
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a nosepiece for fitting to the nasal cavity of the subject, and a capsule-containing member which contains a capsule, the capsule containing the powdered sumatriptan substance to be delivered to the nasal cavity of the subject, wherein the capsule-containing member includes a flow passage in which the capsule is disposed to be rotatable therewithin when an air flow is delivered therethrough, the flow passage including an inlet and an outlet which is in fluid communication with the nosepiece, wherein the device is configured such that, when the nosepiece is fitted to the nasal cavity of the subject, oral exhalation by the subject through the nosepiece acts to close the velum of the subject and drive an air flow through the nasal cavity, with the air flow passing into one nasal passage and out the other nasal passage, thereby achieving a bi-directional air flow, and wherein the powdered sumatriptan substance has a particle size distribution of 10% less than about 20 μ
m, 50% less than about 50 μ
m and 90% less than about 150 μ
m. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A delivery device for delivering a powdered sumatriptan substance to a nasal cavity of a human subject, the delivery device comprising:
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a nosepiece for fitting to the nasal cavity of the subject, and a capsule-containing member which contains a capsule, the capsule containing the powdered sumatriptan substance to be delivered to the nasal cavity of the subject, the powdered sumatriptan substance containing only sumatriptan succinate and no introduced excipients or adjuvants, wherein the capsule-containing member includes a flow passage in which the capsule is disposed to be rotatable therewithin when an air flow is delivered therethrough, the flow passage including an inlet and an outlet which is in fluid communication with the nosepiece, wherein the device is configured such that, when the nosepiece is fitted to the nasal cavity of the subject, oral exhalation by the subject through the nosepiece acts to close the velum of the subject and drive an air flow through the nasal cavity, with the air flow passing into one nasal passage and out the other nasal passage, thereby achieving a bi-directional air flow, and wherein the powdered sumatriptan substance has a particle size distribution of 10% less than about 20 μ
m, 50% less than about 50 μ
m and 90% less than about 150 μ
m. - View Dependent Claims (16)
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17. A nasal delivery device for delivering powdered sumatriptan to a nasal cavity of a human subject, the delivery device comprising:
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a nosepiece for fitting to the nasal cavity of the subject, and a capsule-containing member which contains a capsule, the capsule containing the powdered sumatriptan to be delivered to the nasal cavity of the subject, wherein the capsule-containing member includes a flow passage in which the capsule is disposed to be rotatable therewithin when an air flow is delivered therethrough, the flow passage including an inlet and an outlet which is in fluid communication with the nosepiece, and wherein the device is configured such that when, the nosepiece is fitted to the nasal cavity of the subject, oral exhalation by the subject through the nosepiece acts to close the velum of the subject and drive an air flow through the nasal cavity, with the air flow passing into one nasal passage and out the other nasal passage, thereby achieving a bi-directional air flow, and wherein the powdered sumatriptan has a particle size distribution of 10% less than about 20 μ
m, 50% less than about 50 μ
m and 90% less than about 150 μ
m. - View Dependent Claims (18, 19, 20)
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Specification