Macular pigment measurement device with data quality indexing feature

• US 8,876,293 B2
• Filed: 03/08/2013
• Issued: 11/04/2014
• Est. Priority Date: 10/31/2012
• Status: Active Grant

• Current Assignee: Zeavision LLC
• Original Assignee: Zeavision LLC
• Inventors: Gierhart, Dennis L., Barber, Christopher Gerald, Grover, Malcolm Stuart
• Primary Examiner(s): HASAN, MOHAMMED A
• Application Number:
  US13/791,145
• Publication Number:
  US 20140118698A1
• Time in Patent Office: 606 Days
• Field of Search: 351200-246
• US Class Current: 351/222
• CPC Class Codes: A61B 3/0008 provided with illuminating means A61B3/117 takes precedence; goniolenses used for laser treatment A61F9/009; illuminating means for optical instruments G02B27/00
• CPC Class Codes: A61B 3/02 Subjective types, i.e. testing apparatus requiring the active assistance of the patient
• CPC Class Codes: A61B 3/12 for looking at the eye fundus, e.g. ophthalmoscopes A61B3/13 takes precedence

Abstract

A system measures macular pigment of a macula of a human eye of a subject. The system comprises a light source having a first light and a second light that modulate at variable frequencies, an input device for receiving an input indicating the frequency at which the user perceives the modulation of the first light and a second light, a display device, at least one processor, and one or more memory devices. The one or more memory devices storing instructions that, when executed by at least one processor, cause the system to (i) display, on the display device, test data corresponding to the user'"'"'s inputs from the input device, (ii) determine whether the test data are valid or invalid through a curve-fitting algorithm, (iii) automatically indicate that the test data are valid or invalid.

Claims

1. A measurement system for measuring macular pigment from an eye of a subject, comprising:

a light source having a first light and a second light that modulates at variable frequencies;

an input device for receiving an input indicating the frequency at which the user perceives the modulation of the first light and a second light;

a display device;

at least one processor; and

one or more memory devices storing instructions that, when executed by at least one processor, cause the system to;

display, on the display device, test data corresponding to the user'"'"'s inputs from the input device,

determine whether the test data are valid or invalid through a curve-fitting algorithm,

automatically indicate that the test data are valid or invalid.

2. The system of claim 1, wherein the modulation decreases until reaching the modulation frequency at which the user indicates that he or she perceives the modulation.

3. The system of claim 1, wherein the modulation frequency at which the user provides an input is between about 15 Hz and about 35 Hz.

4. The system of claim 1, wherein the first light is blue and the second light is green.

5. The system of claim 1, wherein the display device further displays the curve that is fitted to the test data.

6. The system of claim 1, wherein the instructions cause the system to display, on the display device, a macular-pigment value indicative of the amount of the patient'"'"'s macular pigment.

7. The system of claim 6, wherein the macular-pigment value is displayed on a scaled bar graph.

8. The system of claim 1, wherein the display device provides the automatic indication of whether the test results are valid or invalid.

9. The system of claim 8, wherein the automatic indication includes a message field providing a message.

10. The system of claim 8, wherein the automatic indication includes the use of at least two colors, a first color indicating the test data is valid, a second color indicating the test data is invalid.

11. A measurement system for measuring macular pigment from an eye of a subject, comprising:

a light source arranged to be viewed by the subject, the light source comprising a first light and a second light arranged to undergo a modulation in opposing phases, the modulation decreasing from an initial modulation frequency at which an initial flicker of the first light and second light is not perceivable by the subject, the light source capable of providing a plurality of different ratios of the amount of the first light relative to the second light;

an input device for receiving inputs from the subject to indicate when he or she perceives a flicker in the light source; and

a display device for displaying (i) test data points corresponding to the user'"'"'s inputs at the plurality of different ratios of the amount of the first light relative to the second light and (ii) an automatic indication of whether the test data is acceptable or unacceptable.

12. The system of claim 11, wherein the decreasing of the modulation frequency is stopped when the user provides an input indicating that the flicker is perceived.

13. The system of claim 11, wherein the modulation frequency is decreased at a rate of between 3 Hz per second and 7 Hz per second.

14. The system of claim 11, wherein the display device displays a macular-pigment value for the subject in a scaled bar graph.

15. The system of claim 11, wherein the automatic indication includes a message field providing a message.

16. The system of claim 11, wherein the automatic indication includes the use of at least two colors, a first color indicating the test data is valid, a second color indicating the test data is invalid.

17. The system of claim 11 , wherein the display device further includes a curve that is fitted to test data.

18. The system of claim 11, wherein the first light is blue and the second light is green.