Bone repair putty

• US 8,876,532 B2
• Filed: 10/22/2010
• Issued: 11/04/2014
• Est. Priority Date: 07/31/2002
• Status: Active Grant

• Current Assignee: DENTSPLY International Incorporated (Astrazeneca PLC)
• Original Assignee: DENTSPLY International Incorporated (Astrazeneca PLC)
• Inventors: Atkinson, Brent L., Hanks, Tracey S.
• Primary Examiner(s): Singh, Sunil K
• Application Number:
  US12/910,195
• Publication Number:
  US 20120101535A1
• Time in Patent Office: 1,474 Days
• Field of Search: 424/549, 424/422, 424/93.7, 433172-176, 433/226
• US Class Current: 433/226
• CPC Class Codes: A61L 2430/02 for reconstruction of bones; weight-bearing implants
• CPC Class Codes: A61L 27/48 with macromolecular fillers
• CPC Class Codes: A61L 27/58 Materials at least partially resorbable by the body
• CPC Class Codes: A61P 19/08 for bone diseases, e.g. rachitism, Paget's disease
• CPC Class Codes: C08L 1/28 Alkyl ethers
• CPC Class Codes: C08L 5/08 Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof

Abstract

A bone repair material is described that is of putty-like consistency, particularly useful for repairing dental bony defects such as those caused by bone loss resulting from moderate or severe periodontitis, augmenting of bony defects of the alveolar ridge, filling tooth extraction sites, or sinus elevation grafting. The repair material includes a porous, resorbable particulate that is bone-derived or derived from bone-like hydroxyapatite or synthetic hydroxyapatite; and, a resorbable carrier, such as high molecular weight polysaccharides, such as hyaluronic acid. A high concentration of particulate in the putty enhances bone repair and requires a high concentration of carrier to retain the putty at the defect site. For a particulate density of about 1.2 g/cc such as PEPGEN P-15® Bone Graft, a preferred formulation comprises about 55% percent by weight of the putty suspended in a hyaluronic acid gel of about 1.4×10⁶ daltons molecular weight and a final concentration of about 56 mg/cc which material adheres to a bony periodontal defect and does not excessively expand or migrate from the defect when held in place by a conventional flap closure.

Claims

1. A method of treating bone loss and repairs thereof, comprising:

making an incision in gum tissue adjacent a bony defect and reflecting a flap of said tissue to expose said defect;

debriding said defect and adjacent tooth roots at said defect;

placing a bone repair material in said defect; and

closing said tissue flap to cover the treated defect,

wherein the bone repair material, comprises;

a porous, resorbable particulate derived of anorganic bone mineral or natural bone miner or synthetic hydroxyapatite, and

a resorbable carrier gel component for suspending said particulate, said gel component having a sufficiently high molecular weight and concentration wherein concentration of the particulate material is sufficiently high such that the bone repair is facilitated while migration and expansion of said material is minimized.

2. The method of claim 1, wherein the placing the repair material is by spatula, instrumentation, hand, or injection.

3. The method of claim 1, wherein said bone repair material further comprises a P-15 polypeptide sequence of collagen bound to xenogeneic bone material particulates, suspended in a hydroxylpolpyl cellulose (HPC) or a hyaluronic acid or derivatives gel carrier, said material having a putty-like consistency.

4. The method of claim 1, wherein said bone loss and repairs comprise placing said bone putty in a defect on the alveolar ridge, in an extraction socket, to correct sinus elevation defects or to repair an implant dehiscence.