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Antithrombogenic hollow fiber membranes and filters

  • US 8,877,062 B2
  • Filed: 07/12/2010
  • Issued: 11/04/2014
  • Est. Priority Date: 05/15/2009
  • Status: Active Grant
First Claim
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1. A method of performing a procedure selected from hemodialysis, hemofiltration, hemoconcentration, or hemodiafiltration on a subject using a dialysis filter, wherein said filter comprises(a) a hollow fiber membrane comprising a base polymer admixed with from 0.005% to 10% (w/w) of a surface modifying macromolecule, wherein said base polymer is a polysulfone or a polyacrylonitrile, wherein said hollow fiber membrane is antithrombogenic when contacted with blood, wherein said surface modifying macromolecule has a structure according to:

  • (a1) formula (VII);


    FT[B-(Oligo)]n-B-FT



    (VII),wherein Oligo is an oligomeric segment including polypropylene oxide or polytetramethylene oxide and having a theoretical molecular weight of from 500 to 3,000 Daltons;

    B is a hard segment formed from hexamethylene diisocyanate;

    FT is a polyfluoroorgano group; and

    n is an integer from 1 to 10;

    (a2) formula (VIII);

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