Antithrombogenic hollow fiber membranes and filters
First Claim
1. A method of performing a procedure selected from hemodialysis, hemofiltration, hemoconcentration, or hemodiafiltration on a subject using a dialysis filter, wherein said filter comprises(a) a hollow fiber membrane comprising a base polymer admixed with from 0.005% to 10% (w/w) of a surface modifying macromolecule, wherein said base polymer is a polysulfone or a polyacrylonitrile, wherein said hollow fiber membrane is antithrombogenic when contacted with blood, wherein said surface modifying macromolecule has a structure according to:
- (a1) formula (VII);
FT[B-(Oligo)]n-B-FT
(VII),wherein Oligo is an oligomeric segment including polypropylene oxide or polytetramethylene oxide and having a theoretical molecular weight of from 500 to 3,000 Daltons;
B is a hard segment formed from hexamethylene diisocyanate;
FT is a polyfluoroorgano group; and
n is an integer from 1 to 10;
(a2) formula (VIII);
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Accused Products
Abstract
The invention relates to extracorporeal blood circuits, and components thereof (e.g., hollow fiber membranes, potted bundles, and blood tubing), including 0.005% to 10% (w/w) surface modifying macromolecule. The extracorporeal blood circuits have an antithrombogenic surface and can be used in hemofiltration, hemodialysis, hemodiafiltration, hemoconcentration, blood oxygenation, and related uses.
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Citations
41 Claims
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1. A method of performing a procedure selected from hemodialysis, hemofiltration, hemoconcentration, or hemodiafiltration on a subject using a dialysis filter, wherein said filter comprises
(a) a hollow fiber membrane comprising a base polymer admixed with from 0.005% to 10% (w/w) of a surface modifying macromolecule, wherein said base polymer is a polysulfone or a polyacrylonitrile, wherein said hollow fiber membrane is antithrombogenic when contacted with blood, wherein said surface modifying macromolecule has a structure according to: -
(a1) formula (VII);
FT[B-(Oligo)]n-B-FT
(VII),wherein Oligo is an oligomeric segment including polypropylene oxide or polytetramethylene oxide and having a theoretical molecular weight of from 500 to 3,000 Daltons;
B is a hard segment formed from hexamethylene diisocyanate;
FT is a polyfluoroorgano group; and
n is an integer from 1 to 10;(a2) formula (VIII); - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29)
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30. A method of performing a procedure selected from hemodialysis, hemofiltration, hemoconcentration, or hemodiafiltration on a subject using a dialysis filter, wherein said filter comprises a hollow fiber membrane comprising a base polymer admixed with from 0.005% to 10% (w/w) of a surface modifying macromolecule, wherein said hollow fiber membrane is antithrombogenic when contacted with blood, wherein said surface modifying macromolecule has a structure according to:
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(a1) formula (VII);
FT-[B-(Oligo)]n-B-FT
(VII),wherein Oligo is an oligomeric segment including polypropylene oxide or polytetramethylene oxide and having a theoretical molecular weight of from 500 to 3,000 Daltons;
B is a hard segment formed from hexamethylene diisocyanate;
FT is a polyfluoroorgano group; and
n is an integer from 1to 10;(a2 )formula (VIII); - View Dependent Claims (31, 32, 33, 34, 35)
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36. A method of performing a procedure selected from hemodialysis, hemofiltration, hemoconcentration, or hemodiafiltration on a subject using a dialysis filter, wherein said filter comprises a hollow fiber membrane comprising a base polymer admixed with from 0.005% to 10% (w/w) of a surface modifying macromolecule, wherein said hollow fiber membrane is antithrombogenic when contacted with blood, wherein said surface modifying macromolecule has a structure according to:
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(a1) formula (VII);
FT-[B-(Oligo)]n-B-FT
(VII),wherein Oligo is an oligomeric segment including polypropylene oxide or polytetramethylene oxide and having a theoretical molecular weight of from 500 to 3,000 Daltons;
B is a hard segment formed from hexamethylene diisocyanate;
FT is a polyfluoroorgano group; and
n is an integer from 1 to 10;(a2) formula (VIII); - View Dependent Claims (37, 38, 39, 40, 41)
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Specification