Medical device with inflammatory response-reducing coating

• US 8,877,170 B2
• Filed: 02/19/2010
• Issued: 11/04/2014
• Est. Priority Date: 02/21/2009
• Status: Active Grant

• Current Assignee: Sofradim Production
• Original Assignee: Sofradim Production
• Inventors: Ladet, Sebastien, Gravagna, Philippe
• Primary Examiner(s): Sullivan, Daniel
• Assistant Examiner(s): Anthopolos, Peter
• Application Number:
  US12/708,861
• Publication Number:
  US 20100215709A1
• Time in Patent Office: 1,719 Days
• US Class Current: 424/78.17
• CPC Class Codes: A61L 17/005 containing a biologically active substance, e.g. a medicament or a biocide
• CPC Class Codes: A61L 17/145 Coating
• CPC Class Codes: A61L 2300/252 Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
• CPC Class Codes: A61L 2300/256 Antibodies, e.g. immunoglobulins, vaccines
• CPC Class Codes: A61L 2300/406 Antibiotics
• CPC Class Codes: A61L 2300/41 Anti-inflammatory agents, e.g. NSAIDs
• CPC Class Codes: A61L 2300/414 Growth factors
• CPC Class Codes: A61L 2300/43 Hormones, e.g. dexamethasone
• CPC Class Codes: A61L 2300/606 Coatings
• CPC Class Codes: A61L 2400/18 Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
• CPC Class Codes: A61L 2420/02 Methods for coating medical devices
• CPC Class Codes: A61L 31/10 Macromolecular materials
• CPC Class Codes: A61L 31/16 Biologically active materials, e.g. therapeutic substances A61L31/047 takes precedence

Abstract

The present disclosure relates to implantable medical devices having a non-bioabsorbable substrate and an amphiphilic coating covalently bonded to the substrate for reducing the inflammatory response to the device after implantation.

Claims

1. A medical device comprising:

a substrate comprising a graft polymer, wherein the main chain of the graft polymer is non-bioabsorbable and is selected from the group consisting of polyethylene terephthalate, polypropylene, polytetrafluoroethylene, a nylon, a polyurethane, a silicone, an ultra-high molecular weight polyethylene, a polybutester, a polyaryletherketone, and copolymers and combinations thereof; and

an amphiphilic polymer comprising both;

(1) a hydrophilic domain composed of chitosan having a degree of acetylation that is less than or equal to 50%, the hydrophilic domain having an octanol-water partition coefficient (log P_OW) of less than 1.0; and

(2) a hydrophobic domain composed of chitosan having a degree of acetylation that is greater than 50%, the hydrophobic domain having an octanol-water partition coefficient (log P_OW) of greater than 5; and

wherein the hydrophobic domain is covalently bonded to a side chain of the graft polymer via a triazole linkage.

2. The medical device of claim 1, wherein the triazole linkage is produced by cyclization of an azide and an alkyne.

3. The medical device of claim 1, wherein the main chain of the graft polymer is composed of polyethylene terephthalate.

4. The medical device of claim 1, wherein the main chain of the graft polymer is composed of polypropylene.

5. The medical device of claim 1, wherein the hydrophilic domain favors cellular attachment.

6. The medical device of claim 1, wherein the hydrophobic domain provides a barrier.

7. The medical device of claim 1, wherein the medical device is a monofilament.

8. The medical device of claim 1, wherein the medical device is a multifilament.

9. The medical device of claim 1, wherein the medical device is a surgical mesh.

10. The medical device of claim 1, wherein the medical device is a ligature.

11. The medical device of claim 1, wherein the medical device is a suture.

12. The medical device of claim 1, wherein the medical device is a staple.

13. The medical device of claim 1, wherein the medical device is a patch.

14. The medical device of claim 1, wherein the medical device is a sling.

15. The medical device of claim 1, wherein the medical device is a foam.

16. The medical device of claim 1, wherein the medical device is a pellicle.

17. The medical device of claim 1, wherein the medical device is a film.

18. The medical device of claim 1, wherein the medical device is a barrier.