Human placental collagen compositions, and methods of making and using the same
First Claim
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1. A composition comprising placental extracellular matrix (ECM), wherein said placental ECM comprises (i) placental collagen, wherein said collagen comprises between 74% and 92% Type I collagen by weight, 4% to 6% Type III collagen and between 2% to 15% type IV collagen by weight, (ii) glycosaminoglycans, (iii) between 3% and 5% elastin by weight, (iv) less than 0.01% laminin by weight, and (v) less than 0.01% fibronectin by weight.
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Abstract
The present invention provides compositions comprising human placental telopeptide collagen, methods of preparing the compositions, methods of their use and kits comprising the compositions. The compositions, kits and methods are useful, for example, for augmenting or replacing tissue of a mammal.
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9 Claims
- 1. A composition comprising placental extracellular matrix (ECM), wherein said placental ECM comprises (i) placental collagen, wherein said collagen comprises between 74% and 92% Type I collagen by weight, 4% to 6% Type III collagen and between 2% to 15% type IV collagen by weight, (ii) glycosaminoglycans, (iii) between 3% and 5% elastin by weight, (iv) less than 0.01% laminin by weight, and (v) less than 0.01% fibronectin by weight.
Specification