Anti-complement C1s
First Claim
Patent Images
1. A humanized antibody that binds complement C1s protein and comprises light chain CDRs of an antibody light chain variable region comprising amino acid sequence SEQ ID NO:
- 7 and heavy chain CDRs of an antibody heavy chain variable region comprising amino acid sequence SEQ ID NO;
8.
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Accused Products
Abstract
The present disclosure provides antibodies that bind complement C1s protein; and nucleic acid molecules that encode such antibodies. The present disclosure also provides compositions comprising such antibodies, and methods to produce and use such antibodies, nucleic acid molecules, and compositions.
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Citations
25 Claims
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1. A humanized antibody that binds complement C1s protein and comprises light chain CDRs of an antibody light chain variable region comprising amino acid sequence SEQ ID NO:
- 7 and heavy chain CDRs of an antibody heavy chain variable region comprising amino acid sequence SEQ ID NO;
8. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15)
- 7 and heavy chain CDRs of an antibody heavy chain variable region comprising amino acid sequence SEQ ID NO;
- 16. A humanized antibody that specifically binds complement C1s protein, wherein the humanized antibody comprises a heavy chain variable region comprising the amino acid sequence of any one of SEQ ID NOs:
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21. A humanized antibody that specifically binds complement C1s protein, wherein the humanized antibody comprises a light chain variable region comprising the amino acid sequence of any one of SEQ ID NOs:
- 43-45 and a heavy chain variable region comprising the amino acid sequence of any one of SEQ ID NOs;
39-42. - View Dependent Claims (22, 23, 24, 25)
- 43-45 and a heavy chain variable region comprising the amino acid sequence of any one of SEQ ID NOs;
Specification