Cellular extracts
First Claim
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1. A method of increasing collagen protein production and/or collagen gene expression by human skin fibroblasts of a subject, comprising:
- applying a formulation containing from about 1% to about 5% volume/volume of a salmon egg cellular extract formulated in a pharmaceutically acceptable carrier—
to the skin of said subject under conditions such that collagen protein production and/or collagen gene expression is increased in human skin fibroblasts at the site of application, wherein said salmon egg extract comprises about 180 to 260 mg/ml fish egg protein, from about 3.7 to 4.5 grams/100 grams extract fish egg lipids, an osmolarity of from about 330 to 440 mOsm, and a pH of from about 6.5 to 7.0.
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Abstract
The invention describes methods and agents for improving cosmetic appearance, for promoting, improving or restoring health of cells and tissues, preferably skin, and more preferably, for restoring aged or damaged skin to a healthy appearance. The agents include compositions of cells, eggs, cell extracts, egg extracts, and extract components such as purified nucleic acids, polypeptides, lipids, carbohydrates or other natural products.
38 Citations
23 Claims
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1. A method of increasing collagen protein production and/or collagen gene expression by human skin fibroblasts of a subject, comprising:
applying a formulation containing from about 1% to about 5% volume/volume of a salmon egg cellular extract formulated in a pharmaceutically acceptable carrier—
to the skin of said subject under conditions such that collagen protein production and/or collagen gene expression is increased in human skin fibroblasts at the site of application, wherein said salmon egg extract comprises about 180 to 260 mg/ml fish egg protein, from about 3.7 to 4.5 grams/100 grams extract fish egg lipids, an osmolarity of from about 330 to 440 mOsm, and a pH of from about 6.5 to 7.0.- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23)
Specification