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Ultrathin parylene-C semipermeable membranes for biomedical applications

  • US 8,877,489 B2
  • Filed: 01/20/2012
  • Issued: 11/04/2014
  • Est. Priority Date: 12/05/2011
  • Status: Active Grant
First Claim
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1. A synthetic semipermeable membrane apparatus, comprising:

  • a membrane having;

    a smooth front side,a back side,spatially interspersed thin and thick regions between the smooth front side and the back side, anda frame substantially surrounding a perimeter of the smooth front side of the membrane,the smooth front side facilitating the growth of a monolayer of cells,the thicker regions on the back side of the membrane being configured to prevent unwanted cell growth from cells growing on the smooth front side,the thin regions being a predetermined thickness of parylene-c,the predetermined thickness selected from a thickness between 0.01 μ

    m to 5 μ

    m,the thin regions configured to be permeable to protein-sized molecules and impermeable to cells,the thick regions comprising parylene-c and being at least 2 times thicker than the predetermined thickness of the thin regions,the interspersion of the thin and thick regions occurring in a patterned array with an average feature size of about 1 μ

    m to 30 μ

    m, andthe frame configured to reduce unwanted migration of cells growing on the smooth front side of the membrane to the back side of the membrane.

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