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Method of differentiating mammalian progenitor cells into insulin producing pancreatic islet cells

  • US 8,877,497 B2
  • Filed: 05/21/2009
  • Issued: 11/04/2014
  • Est. Priority Date: 05/22/2008
  • Status: Active Grant
First Claim
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1. A method for differentiating hepatic progenitor cells into insulin-producing pancreatic cells, comprising:

  • (a) incubating hepatic progenitor cells expressing albumin and CK19 in serum-free pre-induction media comprising sodium butyrate; and

    , subsequently,(b) incubating the hepatic progenitor cells in induction media comprising knock-out replacement serum;

    for a time sufficient to differentiate the hepatic progenitor cells into insulin-producing pancreatic cells.

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