Compositions comprising receptor-associated protein (RAP) variants specific for LRP2 and uses thereof
First Claim
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1. A polypeptide comprising an amino acid sequence variant of the mature alpha-2-macroglobulin/low density lipoprotein receptor-related protein-associated protein 1 (RAP) consisting of an amino acid sequence having at least 90% sequence identity to the amino acids 200-323 set out in SEQ ID NO:
- 94, wherein said amino acid sequence variant of RAP binds to LRP2 with an affinity that is at least 3-fold greater than binding to LRP1, wherein the RAP variant comprises mutations at two or more of positions 249, 251, 256 and 270.
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Abstract
The present invention relates generally to receptor-selective variants of the low-density lipoprotein receptor-associated protein (RAP) and compositions thereof, methods of generating such variants and methods of using such receptor-selective RAP variant compositions for therapeutic purposes. The invention also relates to antibodies that bind to one or a small subset of CR-containing proteins.
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25 Claims
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1. A polypeptide comprising an amino acid sequence variant of the mature alpha-2-macroglobulin/low density lipoprotein receptor-related protein-associated protein 1 (RAP) consisting of an amino acid sequence having at least 90% sequence identity to the amino acids 200-323 set out in SEQ ID NO:
- 94, wherein said amino acid sequence variant of RAP binds to LRP2 with an affinity that is at least 3-fold greater than binding to LRP1, wherein the RAP variant comprises mutations at two or more of positions 249, 251, 256 and 270.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25)
Specification