Compositions and methods for treating macular degeneration
First Claim
1. A method of retarding the accumulation of a lipofuscin pigment in a retina, comprising administering an effective amount of a pharmaceutical composition to a patient in need thereof, wherein the pharmaceutical composition comprises a substituted C20-D1-3-retinoid, wherein the C20-D1-3-retinoid is selected from the group consisting of C20-D1-3-retinol C20-D1-3-retinol ester, C20-D1-3-retinal and C20-D1-3-pro-vitamin A carotenoids, and a pharmaceutically acceptable carrier.
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Abstract
Methods of retarding formation of a lipofuscin pigment in the retina and of treating or ameliorating the effects of a disease characterized by an accumulation of a lipofuscin pigment in a retina are provided. These methods include the step of administering to a patient in need thereof a substituted C20-retinoid in an amount sufficient to reduce accumulation of a lipofuscin pigment in the retina. Further provided are methods of retarding formation of A2E and/or ATR-dimer by replacing an all-frans-retinal (ATR) substrate with a C20-D3-retinal substrate under conditions sufficient to impede the formation of A2E. Compositions for retarding formation of a lipofuscin pigment in the retina containing a substituted C20-retinoid and a pharmaceutically acceptable carrier are also provided.
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Citations
27 Claims
- 1. A method of retarding the accumulation of a lipofuscin pigment in a retina, comprising administering an effective amount of a pharmaceutical composition to a patient in need thereof, wherein the pharmaceutical composition comprises a substituted C20-D1-3-retinoid, wherein the C20-D1-3-retinoid is selected from the group consisting of C20-D1-3-retinol C20-D1-3-retinol ester, C20-D1-3-retinal and C20-D1-3-pro-vitamin A carotenoids, and a pharmaceutically acceptable carrier.
Specification