Method of delivering a biphosphonate and/or strontium ranelate below the surface of a bone
First Claim
1. A method for delivering a bisphosphonate, strontium ranelate or both below a recess or surface feature of a bone comprising:
- a) combining the bisphosphonate, strontium ranelate or both with a carrier to form a delivery composition, wherein the delivery composition is in the form of one selected from the group consisting of a solid, particles and a aggregation of particlesb) placing the delivery composition into the recess or surface feature of the bonec) placing an impact device atop the delivery composition or seating a fastening device into the recess or surface feature atop the delivery composition; and
d) using mechanical force of the impact device or the fastening device to crush or break the delivery composition while driving an effective amount of the delivery composition about 1 mm to about 10 mm delivering an effective amount of the delivery composition below the recess or surface feature of the bone.
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Accused Products
Abstract
A method for delivering a bisphosphonate and/or strontium ranelate below the surface of a bone using a mechanical force. The method includes the steps of combining a bisphosphonate and/or strontium ranelate with a carrier to form a delivery composition and delivering an effective amount of the delivery composition below the surface of the bone with a mechanical force. Also provided is a method for strengthening a portion of a bone. This method includes the step of delivering an effective amount of a bisphosphonate and/or strontium ranelate below the surface of a portion of a bone with a mechanical force.
64 Citations
19 Claims
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1. A method for delivering a bisphosphonate, strontium ranelate or both below a recess or surface feature of a bone comprising:
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a) combining the bisphosphonate, strontium ranelate or both with a carrier to form a delivery composition, wherein the delivery composition is in the form of one selected from the group consisting of a solid, particles and a aggregation of particles b) placing the delivery composition into the recess or surface feature of the bone c) placing an impact device atop the delivery composition or seating a fastening device into the recess or surface feature atop the delivery composition; and d) using mechanical force of the impact device or the fastening device to crush or break the delivery composition while driving an effective amount of the delivery composition about 1 mm to about 10 mm delivering an effective amount of the delivery composition below the recess or surface feature of the bone. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14)
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15. A method for strengthening a portion of a bone comprising delivering an effective amount of bisphosphonate, strontium ranelate, or both below a recess or surface feature of a portion of a bone by:
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a) placing the bisphosphonate, strontium ranelate, or both into the recess or surface feature of the bone, wherein the bisphosphonate, strontium ranelate, or both is in the form of one selected from the group consisting of a solid, particles, and an aggregation of particles; b) placing an impact device atop the bisphosphonate, strontium ranelate, or both;
or seating a fastening device into recess or surface feature atop the bisphosphonate, strontium ranelate, or both; andc) using the impact device or the fastening device to crush or break the bisphosphonate, strontium ranelate, or both while driving an effective amount of the bisphosphonate, strontium ranelate, or both about 1 mm to about 10 mm below the surface of the bone. - View Dependent Claims (16, 17, 18, 19)
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Specification