Devices, systems, and methods for epicardial navigation

• US 8,882,765 B2
• Filed: 02/05/2013
• Issued: 11/11/2014
• Est. Priority Date: 01/23/2007
• Status: Active Grant

• Current Assignee: CVDEVICES, LLC
• Original Assignee: CVDEVICES, LLC
• Inventors: Navia, Jose A. Sr., Kassab, Ghassan S.
• Primary Examiner(s): Peffley, Michael
• Assistant Examiner(s): VAHDAT, KHADIJEH A
• Application Number:
  US13/759,579
• Publication Number:
  US 20130218156A1
• Time in Patent Office: 644 Days
• Field of Search: 606 22- 31, 606 41- 50, 607/122, 600/424
• US Class Current: 606/41
• CPC Class Codes: A61B 17/3478 Endoscopic needles, e.g. for infusion biopsy needles A61B10/0233; catheters with injection needles A61M25/0067
• CPC Class Codes: A61B 18/1492 having a flexible, catheter-like structure, e.g. for heart ablation A61B18/1477 takes precedence
• CPC Class Codes: A61B 2017/00243 cardiac
• CPC Class Codes: A61B 2017/00247 Making holes in the wall of the heart, e.g. laser Myocardial revascularization
• CPC Class Codes: A61B 2017/308 with suction cups
• CPC Class Codes: A61B 2018/00291 using suction
• CPC Class Codes: A61B 2018/00375 Ostium, e.g. ostium of pulmonary vein or artery
• CPC Class Codes: A61B 2018/00392 Transmyocardial revascularisation
• CPC Class Codes: A61B 2018/00839 Bioelectrical parameters, e.g. ECG, EEG
• CPC Class Codes: A61B 34/73 Manipulators for magnetic surgery

Abstract

Devices, systems, and methods for epicardial navigation. In at least one exemplary embodiment of a system for navigating an elongated body on a surface of a tissue of the present disclosure, the system comprises (a) an internal elongated body comprising a distal end and a first element positioned at or near the distal end of the internal elongated body, the internal elongated body devoid of an ablation contact, and (b) an external elongated body comprising a distal end and a second element and an ablation contact positioned at or near the distal end of the external elongated body, the ablation contact being configured to remove or destroy tissue.

Claims

1. A system for navigating an elongated body on a surface of a tissue, comprising:

an internal elongated body comprising a distal end and a first element positioned at or near the distal end of the internal elongated body, the internal elongated body devoid of an ablation contact; and

an external elongated body comprising a distal end and a second element and an ablation contact positioned at or near the distal end of the external elongated body, the ablation contact being configured to remove or destroy tissue, wherein the first element and the second element are magnetically attracted to each other;

wherein when a portion of the external elongated body is positioned on or adjacent to a first surface of a tissue and when a portion of the internal elongated body is positioned on or adjacent to an opposing surface of the tissue, manipulation of the internal elongated body directs movement of the external elongated body to a first location to facilitate removal or destruction of tissue at the first surface at a first location; and

wherein the external elongated body is further operable to remove or destroy tissue at the first surface at a second location directed by the internal elongated body without moving the internal elongated body.

2. The system of claim 1, wherein at least one of the first element and/or the second element comprises a magnet, and wherein the other of the first element and/or the second element comprises a magnetically-attractive non-magnet material if the first element and the second element do not both comprise magnets, and wherein the internal elongated body and the external elongated body are each selected from the group consisting of a catheter and a wire.

3. The system of claim 1, wherein the external elongated body is further operable to destroy or remove tissue along the first surface between the first location and the second location without moving the internal elongated body.

4. The system of claim 1, wherein the first element of the internal elongated body comprises a first electrode capable of transitioning between a magnetized state, in which the first electrode attracts the second element of the external elongated body, and a nonmagnetized state, in which the first electrode does not significantly attract the second element of the external elongated body.

5. The system of claim 4, wherein the internal elongated body further comprises a second electrode positioned at or near the distal end of the internal elongated body, the second electrode of the internal elongated body being capable of transitioning between a magnetized state, in which the second electrode attracts the second element of the external elongated body, and a nonmagnetized state, in which the second electrode does not significantly attract the second element of the external elongated body.

6. The system of claim 5, wherein the internal elongated body further comprises a third electrode, the third electrode is positioned at or near the distal end of the internal elongated body and the third electrode is capable of transitioning between a magnetized state, in which the third electrode attracts the second element of the external elongated body, and a nonmagnetized state, in which the third electrode does not significantly attract the second element of the external elongated body, and wherein the internal elongated body is capable of forming a loop within a heart such that the first, second, and third electrodes are located within the heart.

7. The system of claim 6, wherein the internal elongated body further comprises a fourth electrode, the fourth electrode is positioned at or near the distal end of the internal elongated body, the fourth electrode is capable of transitioning between a magnetized state, in which the fourth electrode attracts the second element of the external elongated body, and a nonmagnetized state, in which the fourth electrode does not significantly attract the second element of the external elongated body, and wherein the internal elongated body is capable of forming a loop within the heart such that the first, second, third, and fourth electrodes are located within the heart.

8. The system of claim 1, wherein the internal elongated body further comprises a pair of excitation electrodes positioned at or near the distal end of the internal elongated body and a pair of detection electrodes positioned on the internal elongated body between the pair of the excitation electrodes, the pair of excitation electrodes and the pair of detection electrodes connected to a processor capable of collecting conductance data and further capable of determining a profile of a body lumen based upon conductance data obtained using the pair of detection electrodes in connection with at least one fluid injection.

9. The system of claim 8, wherein the internal elongated body further comprises a passageway for passing a fluid through the internal elongated body to the body lumen, and wherein the conductance data is determined at each of a plurality of locations.

10. The system of claim 9, wherein the conductance data comprises a first conductance value determined at each of the plurality of locations when the pair of excitation electrodes and the pair of detection electrodes are immersed in a first fluid with a first conductivity and a second conductance value determined at each of the plurality of locations when the pair of excitation electrodes and the pair of detection electrodes are immersed in a second fluid with a second conductivity, wherein the first conductivity does not equal the second conductivity.

11. The system of claim 1, wherein the second element of the external elongated body comprises an external elongated body magnet comprising a first electrode capable of transitioning between a magnetized state, in which the first electrode attracts the first element of the internal elongated body, and a nonmagnetized state, in which the first electrode does not significantly attract the first element of the internal elongated body.

12. The system of claim 11, wherein the external elongated body further comprises a second electrode positioned at or near the distal end of the external elongated body, the second electrode of the external elongated body being capable of transitioning between a magnetized state, in which the second electrode attracts the first element of the internal elongated body, and a nonmagnetized state, in which the second electrode does not significantly attract the first element of the internal elongated body.

13. The system of claim 1, wherein the external elongated body further comprises a third element positioned at or near the distal end of the external elongated body, the third element selected from the group consisting of a second external elongated body magnet and a magnetically-attractive non-magnet material.

14. The system of claim 1, further comprising:

an engagement elongated body comprising a proximal end, a distal end, a first lumen extending between the proximal end and the distal end, a vacuum port located at or near the proximal end of the engagement elongated body in communication with the first lumen of the engagement elongated body and capable of operative connection to a vacuum source, and a suction port located at or near the distal end of the engagement elongated body and configured to removably attach to a targeted tissue on the interior of a wall of a heart and capable of forming a reversible seal with the targeted tissue when the vacuum source is operatively attached to the vacuum port; and

wherein the external elongated body is configured for at least partial insertion into the first lumen of the engagement elongated body.

15. A system for navigating an elongated body on a surface of a tissue, comprising:

an internal elongated body comprising a distal end and a first element positioned at or near the distal end of the internal elongated body, the internal elongated body devoid of an ablation contact; and

an external elongated body comprising a distal end and a second element and an ablation contact positioned at or near the distal end of the external elongated body, the ablation contact being configured to remove or destroy tissue, wherein the first element and the second element are magnetically attracted to each other;

wherein at least one of the first element and/or the second element comprises a magnet, and wherein the other of the first element and/or the second element comprises a magnetically-attractive non-magnet material if the first element and the second element do not both comprise magnets;

wherein the internal elongated body and the external elongated body are each selected from the group consisting of a catheter and a wire;

wherein when a portion of the external elongated body is positioned on or adjacent to a first surface of a tissue and when a portion of the internal elongated body is positioned on or adjacent to an opposing surface of the tissue, manipulation of the internal elongated body directs movement of the external elongated body to a first location to facilitate removal or destruction of tissue at the first surface at a first location; and

wherein the external elongated body is further operable to remove or destroy tissue at the first surface at a second location and along the first surface between the first location and the second location directed by the internal elongated body without moving the internal elongated body.

16. A method of ablating a tissue, the method comprising the steps of:

positioning at least a portion of an internal elongated body adjacent to a first surface of a tissue, the internal elongated body comprising a distal end and a first element positioned at or near the distal end of the internal elongated body, the internal elongated body devoid of an ablation contact;

positioning at least a portion of an external elongated body adjacent to an opposing surface of the tissue, the external elongated body comprising a distal end and a second element and an ablation contact positioned at or near the distal end of the external elongated body, the ablation contact being configured to remove or destroy tissue, wherein the first element and the second element are magnetically attracted to each other;

manipulating the internal elongated body to direct the ablation contact of the external elongated body to a first location on the first surface of the tissue;

first ablating the first location on the first surface of the tissue using the external elongated body; and

second ablating a second location on the first surface of the tissue using the external elongated body directed by the internal elongated body without moving the internal elongated body.

17. The method of claim 16, wherein the step of second ablating further comprises ablating along the first surface between the first location and the second location.

18. The method of claim 16, wherein the first surface of the tissue comprises an endocardial surface of a cardiac tissue, and wherein the opposing surface of the tissue comprises an epicardial surface of the cardiac tissue.

19. The method of claim 18, wherein:

the step of manipulating the internal elongated body comprises (i) engaging the first element of the internal elongated body with the second element of the external elongated body such that moving the first element of the internal elongated body moves the second element of the external elongated body, and (ii) moving the first element of the internal elongated body along the endocardial surface of the cardiac tissue such that the ablation contact of the external elongated body moves along the epicardial surface of the cardiac tissue to the first location on the epicardial surface of the cardiac tissue.

20. The method of claim 16, wherein the internal elongated body comprises a plurality electrodes positioned at or near the distal end of the internal elongated body, wherein the internal elongated body forms a loop within a heart, such that each of the plurality of electrodes are located within the heart, and wherein the method further comprises the step of:

ablating the first surface of the tissue in a specified circumference, the circumference being approximately defined by the loop of the internal elongated body.