Biosensor measurement system and method for detecting abnormal waveform in biosensor

• US 8,882,987 B2
• Filed: 07/26/2007
• Issued: 11/11/2014
• Est. Priority Date: 07/26/2006
• Status: Active Grant

• Current Assignee: PHC Holdings Corporation
• Original Assignee: Panasonic Healthcare Company Limited (PHC Holdings Corporation)
• Inventors: Yoshioka, Toshiharu, Yamanishi, Eriko, Tokunaga, Hiroyuki
• Primary Examiner(s): DINH, BACH T
• Application Number:
  US12/375,106
• Publication Number:
  US 20090205976A1
• Time in Patent Office: 2,665 Days
• Field of Search: 20440301-40315, 205/777.5, 205/778, 205/792
• US Class Current: 205/777.5
• CPC Class Codes: G01N 27/3271 Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood amperometry per se G01N27/49; aspects concerning the enzyme reagent C12Q1/001
• CPC Class Codes: G01N 27/3274 Corrective measures, e.g. error detection, compensation for temperature or hematocrit, calibration coding of calibration information G01N33/48771
• CPC Class Codes: G01N 27/416 Systems G01N27/27 takes precedence

Abstract

A biosensor measurement system and a method for detecting abnormal measurement in a biosensor, which can significantly enhance the measurement precision without depending on the user'"'"'s operation manner or the like, can be provided. A voltage application pattern for applying a voltage to a working electrode, a counter electrode, and a detection electrode has a halt period between a first application period and a second application period, and a reduction current measurement value obtained in the first application period is compared with a reduction current measurement value obtained in the second application period, and the measurement values are not outputted when a difference between the measurement values is outside a predetermined range.

Claims

1. A method comprising

detecting an abnormal waveform in a biosensor, which includes at least a working electrode and a counter electrode and measures an oxidation or reduction current value between the working electrode and the counter electrode, to determine a quantity of a base substance,

wherein the detecting of the abnormal waveform is performed by

applying a voltage between the working electrode and the counter electrode based on a voltage application pattern having a halt period between a first application period and a second application period,

comparing the oxidation or reduction current measurement value obtained in the first application period of applying the voltage with the oxidation or reduction current measurement value obtained in the second application period of applying the voltage, and

determining that the oxidation or reduction current measurement value obtained in the first application period and the oxidation or reduction current measurement value obtained in the second application period are not output when a difference between the oxidation or reduction current measurement value obtained in the first application period and the oxidation or reduction current measurement value obtained in the second application period is outside a predetermined range;

obtaining P values in formula (1) in the first and second application periods, when the voltage is applied according to the voltage application pattern,

P(t)=X(t)−

X(t−

const) 

 

(1),

wherein ,

t represents time,

T0=first application period start time,

T1=first application period end time,

T2=second application period start time,

T3=second application period end time,

X(t) is a measured current value in the second application period ranging from T2 to T3 when the time t ranges within the second application period,

X(t−

const) is a measured current value in the first application period ranging from T0 to T1, and

const represents a time difference between the second application period start time T2 and the first application period start time T0;

comparing the X(t−

const) in the first application period with the X(t) in the second application period; and

outputting no measurement values when a difference P value between the X(t−

const) and X(t) is outside a predetermined range.