Pharmaceutical compositions comprising polymeric binders with non-hydrolysable their use in treating celiac disease
First Claim
1. A method for preventing or decreasing gluten'"'"'s deleterious effects on the gastrointestinal mucosa in a patient in need thereof, said method comprising administering to said patient a pharmaceutically effective amount of a synthetic polymer or copolymer, the synthetic polymer or copolymer comprising one or more of:
- (a) a copolymer of hydroxyethyl methacrylate (HEMA) and 4-styrene sulfonic acid or a salt thereof;
(b) a copolymer of HEMA and sulfopropyl methacrylate or a salt thereof;
(c) a polymer of 4-styrene sulfonic acid or a salt thereof; and
/or(d) a polymer of sulfopropyl methacrylate or a salt thereof,wherein said synthetic polymer or copolymer is able to bind to gluten, and/or bind to peptides derived from the degradation of gluten, in the gastrointestinal tract.
3 Assignments
0 Petitions
Accused Products
Abstract
A pharmaceutical composition comprising a polymeric binder including a high molecular weight synthetic polymer having a backbone constituted of non hydrolysable covalent bonds, said polymer being able to form electrostatic bonds at a pH lower than the isoelectric point of gluten and peptides derived from the degradation of gluten, and being able to bind to gluten or peptides derived from the degradation of gluten in the gastrointestinal tract, and a pharmaceutically acceptable carrier. Methods of using the polymeric binder for binding gluten or a peptide derived from the degradation of gluten, for decreasing the degradation of gluten into toxic peptides or for decreasing interaction of gluten or peptides derived from the degradation of gluten with the gastrointestinal mucosa.
12 Citations
19 Claims
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1. A method for preventing or decreasing gluten'"'"'s deleterious effects on the gastrointestinal mucosa in a patient in need thereof, said method comprising administering to said patient a pharmaceutically effective amount of a synthetic polymer or copolymer, the synthetic polymer or copolymer comprising one or more of:
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(a) a copolymer of hydroxyethyl methacrylate (HEMA) and 4-styrene sulfonic acid or a salt thereof; (b) a copolymer of HEMA and sulfopropyl methacrylate or a salt thereof; (c) a polymer of 4-styrene sulfonic acid or a salt thereof; and
/or(d) a polymer of sulfopropyl methacrylate or a salt thereof, wherein said synthetic polymer or copolymer is able to bind to gluten, and/or bind to peptides derived from the degradation of gluten, in the gastrointestinal tract. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19)
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Specification