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Targeting rare human PCSK9 variants for cholesterol treatment

  • US 8,883,157 B1
  • Filed: 12/23/2013
  • Issued: 11/11/2014
  • Est. Priority Date: 12/17/2013
  • Status: Active Grant
First Claim
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1. A method of reducing cholesterol level or maintaining previously reduced cholesterol level in a human in need thereof comprisinga. selecting a human comprisinga nucleotide sequence encoding a proprotein convertase subtilisin/kexin type 9 (PCSK9) that comprises a C-terminal domain comprising a mutation E670G in SEQ ID NO:

  • 1; and

    b. administering to said human an antibody or antibody fragment that specifically binds a PCSK9 amino acid sequence encoded by said nucleotide sequence comprised by the human, wherein the antibody comprises a VH domain derived from the recombination of a human VH segment, a human D gene segment and a human JH segment, the human VH segment encoding the framework 1 of SEQ ID NO;

    40 and wherein said human comprises a VH gene segment encoding the framework 1 of SEQ ID NO;

    40.

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