Coatings for drug delivery devices
First Claim
Patent Images
1. A coating for a medical device, the coating comprising a polymer having a formula:
-
—
[CH2—
CH(CH3)]p—
[CH2—
CR3(OH)]q—
[CH2—
CH(CH2OH)y]r—
,wherein R3 is selected from a group consisting of a hydrogen atom and an alkyl group, wherein the coating contains a drug, andp is an integer within a range of between about 30 and about 7,600;
q is an integer within a range of between about 30 and about 7,600;
r is an integer within a range of between 0 and about 7,600; and
y equals 1 if r equals at least 1.
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Abstract
A polymer coating for medical devices based on a polyolefin derivative. A variety of polymers are described to make coatings for medical devices, particularly, for drug delivery stents. The polymers include homo-, co-, and terpolymers having at least one olefin-derived unit and at least one unit derived from vinyl alcohol, allyl alcohol and derivatives thereof.
52 Citations
20 Claims
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1. A coating for a medical device, the coating comprising a polymer having a formula:
-
—
[CH2—
CH(CH3)]p—
[CH2—
CR3(OH)]q—
[CH2—
CH(CH2OH)y]r—
,wherein R3 is selected from a group consisting of a hydrogen atom and an alkyl group, wherein the coating contains a drug, and p is an integer within a range of between about 30 and about 7,600; q is an integer within a range of between about 30 and about 7,600; r is an integer within a range of between 0 and about 7,600; and y equals 1 if r equals at least 1. - View Dependent Claims (2, 3, 4, 5, 6)
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7. A coating for a stent, the coating comprising a polymer having a formula:
-
—
[CH2—
CH(CH3)]p—
[CH2—
CR3(OH)]q—
[CH2—
CH(CH2OH)y]r—
,wherein R3 is selected from a group consisting of a hydrogen atom and an alkyl group; p is an integer within a range of between about 30 and about 7,600; q is an integer within a range of between about 30 and about 7,600; r is an integer within a range of between 0 and about 7,600; and y equals 1 if r equals at least 1. - View Dependent Claims (8, 9, 10, 11, 12, 13, 14)
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15. A coating for a medical device, the coating comprises a terpolymer which is a product of copolymerization of an olefin monomer and two different monounsaturated hydroxylated monomers, wherein the coating contains a drug;
wherein the two different monounsaturated hydroxylated monomers are selected from a group consisting of α
-methvinyl alcohol, allyl alcohol, methallyl alcohol, 1-hydroxy-2-methyl ethylene, 1-acetoxy-2-methyl propene, 3-butene-1-ol, 3-butene-2-ol, 2-butene-1-ol, 3-acetoxy-3-butene, and 4-acetoxy-3-butene.- View Dependent Claims (16, 17, 18, 19, 20)
Specification