Nutritional compositions with coated lipid globules

• US 8,883,219 B2
• Filed: 12/11/2009
• Issued: 11/11/2014
• Est. Priority Date: 12/11/2008
• Status: Active Grant

• Current Assignee: nv nutricia
• Original Assignee: nv nutricia
• Inventors: Van Der Beek, Eline Marleen, Speelmans, Gelske, Oosting, Annemarie, Van Baalen, Antonie, Abrahamse-Berkenveld, Marieke, Boehm, Gnther
• Primary Examiner(s): Maewall, Snigdha
• Application Number:
  US13/133,924
• Publication Number:
  US 20110300225A1
• Time in Patent Office: 1,796 Days
• Field of Search: None
• US Class Current: 424/498
• CPC Class Codes: A23L 33/115 Fatty acids or derivatives thereof; Fats or oils
• CPC Class Codes: A23L 33/12 Fatty acids or derivatives thereof
• CPC Class Codes: A23L 33/40 Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula
• CPC Class Codes: A23V 2002/00 Food compositions, function of food ingredients or processes for food or foodstuffs
• CPC Class Codes: A23V 2200/306 having an effect on bone mass, e.g. osteoporosis prevention
• CPC Class Codes: A23V 2250/18 Lipids
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/20 having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
• CPC Class Codes: A61K 31/202 having three or more double bonds, e.g. linolenic eicosanoids, e.g. leukotrienes A61K31/557
• CPC Class Codes: A61K 31/575 substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
• CPC Class Codes: A61K 31/688 both hydroxy compounds having nitrogen atoms, e.g. sphingomyelins
• CPC Class Codes: A61K 35/20 Milk; Whey; Colostrum
• CPC Class Codes: A61K 35/60 Fish, e.g. seahorses; Fish eggs
• CPC Class Codes: A61K 35/66 Microorganisms or materials therefrom fungi, yeasts or candida A61K36/06
• CPC Class Codes: A61K 36/02 Algae
• CPC Class Codes: A61K 36/06 Fungi, e.g. yeasts
• CPC Class Codes: A61K 9/1276 Globules of milk or constituents thereof
• CPC Class Codes: A61K 9/14 Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles microspheres A61K9/16; microcapsules A61K9/50; nanocapsules, nanoparticles of the matrix type A61K9/51
• CPC Class Codes: A61P 19/00 Drugs for skeletal disorders
• CPC Class Codes: A61P 19/08 for bone diseases, e.g. rachitism, Paget's disease
• CPC Class Codes: A61P 19/10 : for osteoporosis
• CPC Class Codes: A61P 3/06 : Antihyperlipidemics

Abstract

The present invention relates to a nutritional composition for infants and/or toddlers comprising a lipid component which has a lipid globules coated with phospholipids. The composition is used for increasing bone mineral content, bone mineral density, preventing osteoporosis, and/or preventing ostopenia.

Claims

1. A method of increasing bone mass density and/or increasing bone mineral content, comprising administering to a human subject between 0 and 36 months of age at risk of developing osteoporosis or in need of enhancement of bone formation and/or bone mass maximation, a composition comprising:

(a) 10 to 50 wt. % of vegetable lipids, based on dry weight of the composition,

(b) 1.0 to 10 wt. % of phospholipids, based on total lipid,

(c) glycosphingolipids, and

(d) cholesterol,

wherein the lipids comprise at least 16 wt. % palmitic acid based on total fatty acids of the composition, and

wherein the vegetable lipids and the phospholipids are in lipid globules with a core comprising said vegetable lipids and a coating comprising said phospholipids lipids.

2. The method according to claim 1, wherein the lipid globules have:

i) a volume-weighted mode diameter below 1.0 μ

m, and

ii) a diameter of 2 to 12 μ

m in an amount of at less than 45 volume % based on total lipid.

3. The method according to claim 2, wherein the lipid globules have:

(i) a volume-weighted mode diameter in the range of 0.3-0.6 μ

m, and

(ii) a size distribution wherein more than 55 volume % of the lipid globules has a diameter of less than 2 μ

m.

4. The method according to claim 1, wherein the lipid globules have:

(i) a volume-weighted mode diameter above 1.0 μ

m, and

(ii) a diameter of 2 to 12 μ

m in an amount of at least 45 volume % based on total lipid.

5. The method according to claim 4, wherein the lipid globules have:

(i) a volume-weighted mode diameter in the range of 1.0-10 μ

m, and/or

(ii) diameter of 2 to 12 μ

m in an amount of at least 55 volume % based on total lipid.

6. The method according to claim 1, wherein the phospholipids are derived from milk lipids.

7. The method according to claim 1, wherein the composition comprises 1.0 to 25 wt. % of polar lipids based on total lipids, wherein polar lipids are the sum of phospholipids, glycosphingolipids and cholesterol.

8. The method according to claim 1, wherein the composition has a fatty acid profile with a linoleic acid to alpha-linolenic acid weight ratio between 4 and 7.

9. The method according to claim 1, wherein over 75 wt. % of the palmitic acid is in the sn-1 or sn-3 position.

10. The method according to claim 1, wherein the composition further comprises least one lipid selected from the group consisting of fish oil, marine oil, algal oil, fungal oil and microbial oil.

11. The method according to claim 1, wherein the composition further comprises non-digestible oligosaccharides.

15. The method according to claim 5, wherein the lipid globules have a volume-weighted mode diameter between 4.0 μ

m and 8.0 μ

m.

16. The method according to claim 1, wherein the composition further comprises gangliosides.

17. The method according to claim 1, wherein the increasing bone mass density and/or increasing bone mineral content is observed when the human subject has an age above 5 years.

12. A method of treating and/or preventing osteoporosis and/or osteopenia, comprising administering to a human subject between 0 and 36 months of age at risk of developing osteoporosis and/or ostopenia a composition comprising:

(a) 10 to 50 wt. % of vegetable lipids, based on dry weight of the composition,

(b) 1.0 to 10 wt. % of phospholipids, based on total lipid,

(c) glycosphingolipids, and

(d) cholesterol,

wherein the lipids comprise at least 16 wt. % palmitic acid based on total fatty acids of the composition, and

wherein the vegetable lipids and the phospholipids are in lipid globules with a core comprising said vegetable lipids and a coating comprising said phospholipids.

13. The method according to claim 12, wherein the lipid globules have:

i) a volume-weighted mode diameter below 1.0 μ

m, and

ii) a diameter of 2 to 12 μ

m in an amount of at less than 45 volume % based on total lipid.

14. The method according to claim 12, wherein the lipid globules have:

(i) a volume-weighted mode diameter above 1.0 μ

m, and

(ii) a diameter of 2 to 12 μ

m in an amount of at least 45 volume % based on total lipid.