5′ and 2′ BIS-substituted nucleosides and oligomeric compounds prepared therefrom
First Claim
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1. An oligomeric compound comprising one monomer of Formula IV:
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Abstract
The present invention provides modified nucleosides and oligomeric compounds prepared therefrom. More particularly, the present invention provides modified nucleosides having at least one 5′-substituent and a 2′-O-substituent, oligomeric compounds comprising at least one of these modified nucleosides and methods of using the oligomeric compounds. In some embodiments, the oligomeric compounds provided herein are expected to hybridize to a portion of a target RNA resulting in loss of normal function of the target RNA.
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23 Claims
- 1. An oligomeric compound comprising one monomer of Formula IV:
- 14. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and an oligomeric compound comprising one monomer of Formula IV:
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