Combined light source photoacoustic system

• US 8,885,155 B2
• Filed: 04/30/2012
• Issued: 11/11/2014
• Est. Priority Date: 04/30/2012
• Status: Active Grant

• Current Assignee: Covidien LP (Medtronic Plc)
• Original Assignee: Covidien LP (Medtronic Plc)
• Inventors: Li, Youzhi, Chen, Bo
• Primary Examiner(s): Geisel, Kara E
• Assistant Examiner(s): BOLOGNA, DOMINIC JOSEPH
• Application Number:
  US13/459,933
• Publication Number:
  US 20130286379A1
• Time in Patent Office: 925 Days
• Field of Search: 356 39- 42, 356/432, 356/436, 600310-344, 604 20- 21
• US Class Current: 356/40
• CPC Class Codes: A61B 5/0095 by applying light and detecting acoustic waves, i.e. photoacoustic measurements
• CPC Class Codes: G01N 21/1702 with opto-acoustic detection, e.g. for gases or analysing solids

Abstract

A physiological monitoring system may use photoacoustic sensing to determine one or more physiological parameters of a subject. The photoacoustic system may use two light sources (e.g., a high power pulsed laser diode and a continuous wave laser diode) to generate acoustic pressure signals in a subject. One or more light sources (e.g., the high powered pulsed laser diode) may provide a high signal-to-noise ratio. The high signal-to-noise ratio signals may provide high sensitivity for physiological measurements (e.g., cardiac output and temperature measurements). The photoacoustic system may use high powered light sources in combination with other light sources to improve physiological measurements.

Claims

1. A photoacoustic method for determining a physiological parameter, the method comprising:

providing a pulsed photonic signal to a subject from a first light source;

providing a modulated photonic signal to the subject from a second light source;

detecting a first acoustic pressure signal and a second acoustic pressure signal from the subject, wherein the first acoustic pressure signal is caused by absorption of at least some of the pulsed photonic signal by the subject and the second acoustic pressure signal is caused by absorption of at least some of the modulated photonic signal by the subject;

determining a first physiological parameter based on the first acoustic pressure signal; and

determining a second physiological parameter, different from the first physiological parameter, based on the second acoustic pressure signal.

2. The method of claim 1, further comprising:

determining a third physiological parameter based on both the first acoustic pressure signal and the second acoustic pressure signal.

3. The method of claim 1, wherein the first light source comprises one or more pulsed laser diodes.

4. The method of claim 1, wherein the first light source comprises one or more emitters configured to emit light with a wavelength between 900 nm and 910 nm.

5. The method of claim 1, wherein the second light source comprises one or more continuous wave laser diodes.

6. The method of claim 5, wherein the second light source comprises one or more emitters configured to emit light of two different wavelengths between 600 nm and 1200 nm.

7. The method of claim 6, wherein detecting the second acoustic pressure signal comprises detecting a first component corresponding to a first of the two different wavelengths and detecting a second component corresponding to a second of the two different wavelengths, and wherein determining the second physiological parameter comprises determining the second physiological parameter based at least in part on the first and second components.

8. The method of claim 1, wherein the first light source and the second light source are configured to emit light at different times.

9. The method of claim 1, wherein detecting the first acoustic pressure signal and the second acoustic pressure signal comprises detecting the first acoustic pressure signal and the second acoustic pressure signal using a piezoelectric ultrasound receiver array of at least one dimension.

10. The method of claim 1, wherein the first physiological parameter comprises temperature, cardiac output (CO), intrathoracic blood volume (ITBV), intrathoracic circulatory volume (ITCV), global end-diastolic volume (GEDV), pulmonary circulatory volume (PCV), extravascular lung water (EVLW), or any suitable combination thereof, and wherein the second physiological parameter comprises hemoglobin concentration, blood oxygen saturation, or any suitable combination thereof.

11. The system of claim 1, wherein the first physiological parameter is determined based on the first acoustic pressure signal and not on the second acoustic pressure signal.

12. The method of claim 1, wherein the pulse photonic signal comprises a first wavelength of light and the modulated photonic signal comprises a second wavelength of light different than the first wavelength of light.

13. A photoacoustic system for determining a physiological parameter, the system comprising:

a first light source configured to provide a pulsed photonic signal comprising a first wavelength of light to a subject;

a second light source configured to provide a modulated photonic signal comprising a second wavelength of light, different from the first wavelength of light, to the subject;

at least one acoustic detector configured to detect a first acoustic pressure signal and a second acoustic pressure signal from the subject, wherein the first acoustic pressure signal is caused by absorption of at least some of the pulsed photonic signal by the subject and the second acoustic pressure signal is caused by absorption of at least some of the modulated photonic signal by the subject; and

processing equipment communicatively coupled to the acoustic detector, the processing equipment configured to determine a first physiological parameter based on the first acoustic pressure signal and to determine a second physiological parameter, different from the first physiological parameter, based on the second acoustic pressure signal.

14. The system of claim 13, wherein the processing equipment is further configured to:

determine a third physiological parameter using both the first acoustic pressure signal and the second acoustic pressure signal.

15. The system of claim 13, wherein the first light source comprises one or more pulsed laser diodes.

16. The system of claim 13, wherein the first light source comprises one or more emitters configured to emit light at the first wavelength and wherein the first wavelength is between 900 nm and 910 nm.

17. The system of claim 13, wherein the second light source comprises one or more continuous wave laser diodes.

18. The system of claim 17, wherein the second light source comprises one or more emitters and wherein the modulated photonic signal comprises light of a third wavelength different from the second wavelength, and wherein the second and the third wavelengths are between 600 nm and 1200 nm.

19. The system of claim 18, wherein the second acoustic pressure signal comprises a first component corresponding to the second wavelength and a second component corresponding to the third wavelength, and wherein the processing equipment is further configured to determine the second physiological parameter based on the first and second components.

20. The system of claim 13, wherein the first light source and the second light source are configured to emit light at different times.

21. The system of claim 13, wherein the at least one photoacoustic detector comprises a piezoelectric ultrasound receiver array of at least one dimension.

22. The system of claim 13, wherein the first physiological parameter comprises temperature, cardiac output (CO), intrathoracic blood volume (ITBV), intrathoracic circulatory volume (ITCV), global end-diastolic volume (GEDV), pulmonary circulatory volume (PCV), extravascular lung water (EVLW), or any suitable combination thereof, and wherein the second physiological parameter comprises hemoglobin concentration, blood oxygen saturation, or any suitable combination thereof.

23. The system of claim 13, wherein the first light source, the second light source, and the at least one acoustic detector are disposed within a housing configured to be positioned on a tissue of the subject.