System and method for controlling a heart stimulator

• US 8,886,310 B2
• Filed: 06/09/2006
• Issued: 11/11/2014
• Est. Priority Date: 06/09/2006
• Status: Active Grant

• Current Assignee: St. Jude Medical AB (Abbott Laboratories)
• Original Assignee: St. Jude Medical AB (Abbott Laboratories)
• Inventors: Norn, Kjell, Farazi, Taraneh G.
• Primary Examiner(s): Koharski, Christopher D
• Assistant Examiner(s): So, Elizabeth K
• Application Number:
  US12/303,987
• Publication Number:
  US 20100010555A1
• Time in Patent Office: 3,077 Days
• Field of Search: 607/17, 607/115, 607/116, 607/119
• US Class Current: 607/17
• CPC Class Codes: A61B 5/02405 Determining heart rate variability
• CPC Class Codes: A61B 5/4035 Evaluating the autonomic nervous system
• CPC Class Codes: A61N 1/36114 Cardiac control, e.g. by vagal stimulation stimulating the heart A61N1/362
• CPC Class Codes: A61N 1/3622 comprising two or more electrodes co-operating with different heart regions
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371

Abstract

In a system and method for controlling an implantable stimulator capable of producing pacing pulses to be delivered to cardiac tissue, as well as vagal stimulation pulses to be delivered to vagus nerve sites, upon detection of a premature cardiac event, such as a premature ventricular or atrial contraction, a simulated heart rate turbulence (HRT) procedure is applied if the intrinsic heart rate turbulence is weakened or absent. The simulated HRT includes a first phase in which the heart rate is increased, from the existing level, for a number of heart beats, a second phase in which the heart rate is decreased for a number of heart beats, and an optional third phase in which the heart rate is returned to said existing level.

Claims

1. An implantable heart stimulator comprising:

a cardiac pulse generator that generates and emits pacing pulses;

a cardiac lead connected to said cardiac pulse generator and configured to deliver said pacing pulses to cardiac tissue in at least one ventricle of a heart;

at least one cardiac lead carrying an electrode configured to detect electrical signals in the heart representative of cardiac contractions;

a vagal pulse generator that generates and emits vagal stimulation pulses;

at least one vagal lead configured to deliver said vagal stimulation pulses to a vagus nerve site;

a signal processing circuit configured to receive the electrical signals indicative of cardiac contractions and to process the received signals to determine therefrom whether a premature cardiac contraction has occurred, the signal processing circuit being further configured to determine whether heart rate turbulence is present in the received electrical signals in response to the detection of the occurrence of said premature cardiac contractions; and

a controller connected to said signal processing circuit to receive said output therefrom, said controller being configured to initiate a heart rate turbulence procedure to mimic heart rate turbulence by controlling said cardiac pulse generator to increase a rate of emission of said pacing pulses to initially accelerate the heart rate of said heart to an accelerated rate above an existing heart rate upon an occurrence of said premature contraction and the failure to detect heart rate turbulence, and to subsequently decelerate said heart rate to a decelerated rate below said existing heart rate by controlling said vagal stimulation pulse generator to produce a vagal response that decelerates the heart rate.

2. An implantable heart stimulator as claimed in claim 1 wherein said controller controls said pacing pulse stimulator to accelerate said heart rate for a period of time comprising 2 to 4 heartbeats.

3. An implantable heart stimulator as claimed in claim 2 wherein said controller is configured to adjust a duration during which said heart rate is accelerated dependent on patient response.

4. An implantable heart stimulator as claimed in claim 2 wherein said controller is configured to gradually accelerate said heart rate during said period.

5. An implantable heart stimulator as claimed in claim 4 wherein said controller is configured to gradually accelerate said heart rate with an increase of approximately 2% to 4% for each heartbeat.

6. An implantable heart stimulator as claimed in claim 4 wherein said controller is configured to adjust a degree of said gradual acceleration dependent on patient response.

7. An implantable heart stimulator as claimed in claim 1 wherein said controller is configured to control said vagal pulse stimulator to decelerate said heart rate during a period comprising 4 to 15 heartbeats.

8. An implantable heart stimulator as claimed in claim 7 wherein said controller is configured to adjust a duration of said period dependent on patient performance.

9. An implantable heart stimulator as claimed in claim 7 wherein said controller is configured to gradually decrease said heart rate during said period.

10. An implantable heart stimulator as claimed in claim 9 wherein said controller is configured to gradually decelerate said heart rate during said period by decreasing said heartbeat rate between 1% and 5% for each heartbeat.

11. An implantable heart stimulator as claimed in claim 10 wherein said controller is configured to adjust a degree of said gradual decrease of said heart rate dependent on patient response.

12. An implantable heart stimulator as claimed in claim 1 wherein said controller is configured to control said pacing pulse stimulator to increase the heart rate at an end of said heart rate turbulence procedure.

13. An implantable heart stimulator as claimed in claim 12 wherein said controller is configured to increase said heart rate to substantially equal said existing heart rate.

14. An implantable heart stimulator as claimed in claim 13 wherein said signal processing circuit monitors an intrinsic rate of the heart following said heart rate turbulence procedure, and wherein said controller is configured to control said pacing pulse stimulator to increase the heart rate to substantially equal said existing heart rate if said intrinsic rate does not increase to substantially equal said existing heart rate at said end of said heart rate turbulence procedure.

15. An implantable heart stimulator as claimed in claim 1 wherein said signal processing circuit is configured to detect a premature atrial contraction as said premature cardiac contraction.

16. An implantable heart stimulator as claimed in claim 1 wherein said signal processing circuit is configured to detect a premature ventricular contraction as said premature cardiac contraction.

17. An implantable heart stimulator as claimed in claim 1 wherein said signal processing circuit is configured to detect a contraction induced by an intrinsic cardiac event as said premature cardiac contraction.

18. An implantable heart stimulator as claimed in claim 1 wherein said signal processing circuit is configured to detect a contraction induced by delivery of stimulation pulses from said pacing pulse stimulator as said premature cardiac contraction.

19. A non-transitory computer-readable medium encoded with programming instructions for operating an implantable heart stimulator, said implantable heart stimulator comprising

a cardiac pulse generator that generates and emits pacing pulses,

a cardiac lead connected to said cardiac pulse generator and configured to deliver said pacing pulses to cardiac tissue in at least one ventricle of a heart, at least one cardiac lead carrying an electrode configured to detect electrical signals in the heart representative of cardiac contractions,

a vagal pulse generator that generates and emits vagal stimulation pulses, at least one vagal lead configured to deliver said vagal stimulation pulses to a vagus nerve site,

a signal processing circuit and a controller, said programming instructions causing:

said signal processing circuit to receive said electrical signals indicative of cardiac contractions and to determine therefrom whether a premature cardiac contraction has occurred, the signal processing circuit being further configured to determine whether heart rate turbulence is present in response to the detection of the premature cardiac contractions; and

said controller to receive said output from said signal processing circuit and to initiate a heart rate turbulence procedure to mimic heart rate turbulence by controlling said cardiac pulse generator to increase a rate of emission of said pacing pulses to initially accelerate the heart rate of said heart to an accelerated rate above an existing heart rate upon an occurrence of said premature contraction and the failure to detect heart rate turbulence, and to subsequently decelerate said heart rate to a decelerated rate below said existing heart rate by controlling said vagal stimulation pulse generator to produce a vagal response that decelerates the heart rate.

20. A method for stimulating a heart, comprising the steps of;

receiving electrical signals indicative of cardiac contractions;

processing the electrical signals to determine whether a premature cardiac contraction has occurred,

determining whether the patient is experiencing heart rate turbulence;

increasing a pacing rate to initially accelerate the heart rate of a patient'"'"'s heart to an accelerated rate above an existing heart rate upon an occurrence of said premature contraction and a determination that the patient is not experiencing heart rate turbulence; and

delivering vagal stimulation to produce a vagal response to decelerate the heart rate below the existing heart rate subsequent to the delivery of the pacing pulses at the increased pacing rate.