Lung volume reduction devices, methods, and systems

• US 8,888,800 B2
• Filed: 03/13/2012
• Issued: 11/18/2014
• Est. Priority Date: 03/13/2006
• Status: Expired due to Fees

• Current Assignee: EKOS Corporation (Boston Scientific Corporation)
• Original Assignee: PneumRx, Inc. (Boston Scientific Corporation)
• Inventors: Mathis, Mark L., Thompson, David, Aronson, Nathan, Wu, Patrick
• Primary Examiner(s): ANDERSON, GREGORY A
• Application Number:
  US13/418,534
• Publication Number:
  US 20120172909A1
• Time in Patent Office: 980 Days
• Field of Search: 606/151, 606/157, 623/23.64, 623/23.65, 623/23.61
• US Class Current: 606/157
• CPC Class Codes: A61B 1/2676 Bronchoscopes
• CPC Class Codes: A61B 17/12022 Occluding by internal devices, e.g. balloons or releasable wires plugging an opening in the wall of an organ A61B17/0057; occluders for the cervical canal A61F6/146; vas deferens occluders A61F6/20
• CPC Class Codes: A61B 17/12031 complete occlusion
• CPC Class Codes: A61B 17/12104 in an air passage
• CPC Class Codes: A61B 17/12131 characterised by the type of occluding device
• CPC Class Codes: A61B 17/12145 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/12172 having a pre-set deployed three-dimensional shape methods of manufacturing A61B2017/00526
• CPC Class Codes: A61B 17/122 Clamps or clips , e.g. for the umbilical cord for the vas deferens A61F6/206
• CPC Class Codes: A61B 2017/00477 Coupling A61B2017/0046 takes precedence
• CPC Class Codes: A61B 2017/00809 Lung operations
• CPC Class Codes: A61B 2017/1205 Introduction devices
• CPC Class Codes: A61B 2017/12054 Details concerning the detachment of the occluding device from the introduction device
• CPC Class Codes: A61F 2/04 Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts A61F2/18, A61F2/20 take precedence; devices, other than stent-grafts, providing patency to, or preventing collapsing of, tubular structures of the body other than stent-grafts, e.g. stents A61F2/82; instruments specially adapted for placement or removal of stents or stent-grafts A61F2/95
• CPC Class Codes: A61F 2002/043 Bronchi
• CPC Class Codes: A61M 16/04 Tracheal tubes catheters in general A61M25/00
• CPC Class Codes: A61M 16/0406 implanted flow modifiers
• CPC Class Codes: A61M 16/208 Non-controlled one-way valves, e.g. exhalation, check, pop-off non-rebreathing valves
• CPC Class Codes: A61M 2205/0266 Shape memory materials

Abstract

The invention provides improved medical devices, therapeutic treatment systems, and treatment methods for treatment of the lung. A lung volume reduction system includes an implantable device having an elongate body that is sized and shaped for delivery via the airway system to a lung airway of a patient. The implant is inserted and positioned while the implant is in a delivery configuration, and is reconfigured to a deployed configuration so as to locally compress adjacent tissue of the lung, with portions of the elongate body generally moving laterally within the airway so as to laterally compress lung tissue. A plurality of such implants will often be used to treat a lung of a patient.

Claims

1. A method for treating a lung of a patient, the lung including a first airway axial region having a pre-deployment airway axis and a second airway axial region, the method comprising:

compressing a lung tissue volume by urging the first airway axial region laterally away from the pre-deployment airway axis toward the second airway axial region using an implant system extending into the first and second airway axial regions.

2. The method of claim 1, wherein the airway axial regions each comprise elongate lengths of the airway system, each airway axial region extending along an associated airway central axis, wherein the compressed volume of lung tissue is disposed at least in part between the first airway axial region and the second airway axial region and is compressed by laterally urging the airway axial regions together using elongate implant portions extending axially within the airway axial regions.

3. The method of claim 2, wherein the implant system comprises an elongate body having a proximal portion and a distal portion, wherein the distal portion of the elongate body passes through the first airway axial region and engages the second airway axial region, and the proximal portion of the elongate body engages the first airway axial region, the first and second airway axial regions being coupled together axially.

4. The method of claim 3, wherein the lung tissue volume is compressed by bending of the elongate body between the proximal portion and the distal portion, the bending of the elongate body within the airway axial regions urging a bearing surface of the elongate body laterally against an airway lumen surface so as to impose a bend in the airway system between the airway axial regions.

5. The method of claim 4, wherein the bearing surface does not penetrate through the airway surface during deployment of the elongate body.

6. The method of claim 1, wherein a surface is defined between the first and second axial region axes, and further comprising urging a third airway axial region toward the surface from within the third airway axial region so that the compressed volume of lung tissue is disposed at least in part between the surface and the third airway axial region.

7. The method of claim 6, further comprising urging a fourth airway axial region toward the first, second, and third airway axial regions, the compressed lung tissue volume being disposed therebetween.

8. The method of claim 1, further comprising urging a third airway axial region laterally toward a fourth airway axial region from within third and forth airway axial regions, respectively.

9. The method of claim 1, wherein the compressed volume of lung tissue is sufficiently large and is compressed sufficiently to increase tension in an uncompressed volume of the lung such that lung function of the lung is increased.

10. An implant for treating a lung of a patient, the lung including a first airway axial region having an airway axis and a second airway axial region, the implant comprising:

a first elongate body portion having a first local axis;

a second elongate body portion having a second local axis;

an intermediate elongate body portion coupling the first elongate body portion to the second elongate body portion so that the implant is configured to deploy from a first configuration to a second configuration when the first elongate body portion extends axially along the first airway axial region and the second elongate body portion extends axially along the second airway axial region, the intermediate elongate body portion in the second configuration configured to bend so as to urge the first elongate body portion away from the airway axis and compress a lung tissue volume laterally between the first airway axial region and the second airway axial region,

wherein the elongate body portions are included within a continuous elongate body, and wherein the elongate body is biased to bend from the first configuration to the second configuration so as to compress the lung tissue volume by urging a bearing surface of the elongate body laterally against an airway lumen surface so as to impose a bend in the airway system between the airway axial regions.

11. The implant of claim 10, wherein the bearing surface is sized to inhibit penetration through the airway surface during deployment of the elongate body.

12. The implant of claim 11, wherein a third elongate body portion is coupled to the first and second body portions, wherein a surface is defined between the first and second local axes when the implant is in the second configuration, the implant in the second configuration configured to urge a third airway axial region toward the surface from within the third airway axial region so that the compressed volume of lung tissue is disposed at least in part between the surface and the third airway axial region.

13. The implant of claim 12, further comprising a fourth elongate body portion coupled to the third body portion so as to urge a fourth airway axial region toward the first, second, and third airway axial regions when the implant is in the second configuration, the compressed lung tissue volume being disposed therebetween.

14. The implant of claim 10, wherein the compressed volume of lung tissue is sufficiently large and is compressed sufficiently to increase tension in an uncompressed volume of the lung such that lung function of the lung is increased.

15. A method for treating a lung of a patient, the lung including an airway system with a pre-deployment airway axis, the method comprising:

deploying an implant into an axial region of the airway having a first end and a second end so that a proximal end of the implant engages the first end of the axial region, so that a distal end of the implant engages the second end of the axial region, and so that the implant inwardly bends an airway wall portion into the airway between the first end of the axial region and the second end of the axial region laterally away from the pre-deployment airway axis.

16. The method of claim 15, wherein the proximal end of the implant, the distal end of the implant, and the implant between the proximal and distal ends press laterally against the airway so as to compress adjacent lung tissue from within the airway system.

17. An implant for treating a lung of a patient, the lung including an airway having a pre-deployment airway axis, the implant comprising:

an elongate body having a proximal end and a distal end, the implant having an insertion configuration suitable for insertion of the implant into an axial region of the airway so that a proximal end of the implant is adjacent the first end of the axial region and so that a distal end of the implant is adjacent the second end of the axial region, wherein the inserted implant is reconfigurable to a deployed configuration so as to move the airway laterally from the pre-deployment airway axis and impose an inward bend of an airway wall portion into the airway between the first end of the axial region and the second end of the axial region.

18. The implant of claim 17, wherein reconfiguration of the inserted implant from the insertion configuration to the deployed configuration reshapes the implant so that the proximal end of the implant, the distal end of the implant, and the implant between the proximal and distal ends press laterally and atraumatically against the airway so as to compress adjacent lung tissue from within the airway system.