Treatment of Huntington's disease

• US 8,889,125 B2
• Filed: 03/15/2013
• Issued: 11/18/2014
• Est. Priority Date: 03/15/2013
• Status: Active Grant

• Current Assignee: Genix Therapeutics Group, LLC
• Original Assignee: Genix Therapeutics Group, LLC
• Inventors: El-Rashidy, Ragab
• Primary Examiner(s): Ariani, Kade
• Application Number:
  US13/838,631
• Publication Number:
  US 20140271592A1
• Time in Patent Office: 613 Days
• Field of Search: None
• US Class Current: 424/94.1
• CPC Class Codes: A61K 2300/00 Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
• CPC Class Codes: A61K 31/455 Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
• CPC Class Codes: A61K 31/51 Thiamines, e.g. vitamin B1
• CPC Class Codes: A61K 31/7076 containing purines, e.g. adenosine, adenylic acid
• CPC Class Codes: A61K 31/714 Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
• CPC Class Codes: A61K 9/0019 Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner non-active ingredients are additionally classified in A61K47/00
• CPC Class Codes: A61K 9/19 lyophilised , i.e. freeze-dried, solutions or dispersions lyophilised products with subsequent particle size reduction A61K9/14; granules or pellets made by lyphilisation A61K9/1682; solid oral dosage forms made by lyophilisation A61K9/2095; lyophilisation additives A61K47/00

Abstract

The present invention relates to a method of treatment and/or ameliorating the symptoms of Huntington'"'"'s disease comprising the step of administering an effective amount of adenosine triphosphate, co-carboxylase, nicotinamide, and cyanocobalamin in a physiologically acceptable carrier to an individual in need thereof. Preferably, the administration is via intramuscular injection.

Claims

1. A method for ameliorating loss of grip strength in a patient suffering from Huntington'"'"'s Disease which comprises administering to the patient an effective amount of a composition comprising adenosine triphosphate, co-carboxylase, nicotinamide, and cyanocobalamin in a physiologically acceptable carrier, wherein the administration is by intramuscular injection, and wherein the effective amount administered comprises about 10 parts by weight adenosine triphosphate, about 50 parts by weight co-carboxylase, about 20 parts by weight nicotinamide, and about 0.5 parts by weight cyanocobalamin.

2. The method in accordance with claim 1 wherein the intramuscular injection is effected on alternate days.

3. The method in accordance with claim 2 wherein the effective amount administered comprises about 10 milligrams adenosine triphosphate, about 50 milligrams co-carboxylase, about 20 milligrams nicotinamide, and about 0.5 milligrams cyanocobalamin.