Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
DC CAFCFirst Claim
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1. An isolated monoclonal antibody that binds to an epitope of PCSK9 that comprises at least three of amino acid residues 207, 208, 162, 164, 167, 132, 351, 390, 413, 123, 129, 311, 313, or 337 of SEQ ID NO:
- 1, and wherein the monoclonal antibody blocks binding of PCSK9 to LDLR.
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Abstract
Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
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20 Claims
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1. An isolated monoclonal antibody that binds to an epitope of PCSK9 that comprises at least three of amino acid residues 207, 208, 162, 164, 167, 132, 351, 390, 413, 123, 129, 311, 313, or 337 of SEQ ID NO:
- 1, and wherein the monoclonal antibody blocks binding of PCSK9 to LDLR.
- View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10)
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11. An isolated monoclonal antibody specific for binding PCSK9 that binds to at least three of amino acid residues 207, 208, 162, 164, 167, 132, 351, 390, 413, 123, 129, 311, 313, or 337 of SEQ ID NO:
- 1, and wherein the monoclonal antibody blocks binding of PCSK9 to LDLR.
- View Dependent Claims (12, 13, 14, 15, 16, 17, 18)
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19. An isolated monoclonal antibody specific for binding PCSK9 that binds to at least four of amino acid residues 207, 208, 162, 164, 167, 132, 351, 390, 413, 123, 129, 311, 313, or 337 of SEQ ID NO:
- 1, and wherein the monoclonal antibody blocks binding of PCSK9 to LDLR.
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20. An isolated human monoclonal neutralizing antibody that binds to an epitope of PCSK9 containing at least one of amino acids 162, 164, 167, 207 or 208 of SEQ ID NO:
- 1, and wherein the monoclonal antibody blocks binding of PCSK9 to LDLR.
Specification