Method and apparatus to control conduction through the heart to treat cardiac conditions

• US 8,892,197 B2
• Filed: 07/29/2005
• Issued: 11/18/2014
• Est. Priority Date: 07/29/2005
• Status: Active Grant

• Current Assignee: Medtronic Incorporated (Medtronic Plc)
• Original Assignee: Medtronic Incorporated (Medtronic Plc)
• Inventors: Ujhelyi, Michael R., Sigg, Daniel C.
• Primary Examiner(s): Lucchesi, Nicholas
• Assistant Examiner(s): LEE, WENG WAH
• Application Number:
  US11/192,884
• Publication Number:
  US 20070027394A1
• Time in Patent Office: 3,399 Days
• Field of Search: 607/9, 607/120, 600/508, 600/518, 600/509, 600/513
• US Class Current: 600/518
• CPC Class Codes: A61B 5/361 Detecting fibrillation
• CPC Class Codes: A61M 2005/1726 the body parameters being measured at, or proximate to, the infusion site
• CPC Class Codes: A61M 2210/125 Heart
• CPC Class Codes: A61M 2230/04 Heartbeat characteristics, e.g. ECG, blood pressure modulation
• CPC Class Codes: A61M 2230/63 Motion, e.g. physical activity
• CPC Class Codes: A61M 5/14276 specially adapted for implantation
• CPC Class Codes: A61M 5/1723 using feedback of body parameters, e.g. blood-sugar, pressure measurement of body parameters A61B5/00
• CPC Class Codes: A61N 1/0575 with drug delivery
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371
• CPC Class Codes: A61N 1/3682 with a variable atrioventricular delay

Abstract

Control of conduction through a heart is described. A lead with a proximal end and a distal end is provided. The distal end of the lead is inserted into a target area. An agent is delivered through the lead to the target area. Delivery of the agent is monitored via a closed loop feedback system.

Claims

1. A method of treating atrial fibrillation in a patient, the method comprising:

delivering a catheter to AV nodal tissue of the patient;

fixating the catheter to the AV nodal tissue;

determining an occurrence of atrial fibrillation;

delivering a calcium channel blocker agent into the AV nodal tissue to increase AV nodal tissue refractoriness and decrease ventricular rate upon determining the occurrence of atrial fibrillation;

monitoring an electrical response by the heart to the calcium channel blocker agent via a closed loop system, wherein the electrical response comprises at least one of a parameter representative of AV nodal refractoriness and a parameter representative of ventricular rate, wherein the electrical response comprises at least AV conduction time; and

adjusting quantity of the delivered calcium channel blocker agent using the closed loop system based on at least one of the parameter representative of AV nodal refractoriness and the parameter representative of ventricular rate, wherein adjusting quantity of the delivered calcium channel blocker agent using the closed loop system is based at least on AV conduction time.

3. The method of claim 1 further comprising ceasing delivery of the calcium channel blocker agent responsive to determining AV conduction time is lower than 100 ms.

4. The method of claim 3 further comprising:

determining AV conduction time is higher than 100 ms; and

determining AV conduction time is less than 250 ms.

5. The method of claim 4 further comprising continuing delivery of the calcium channel blocker agent responsive to determining AV conduction time is less than 250 ms.

6. The method of claim 1 further comprising determining AV conduction time is higher than 100 ms.

7. The method of claim 6 further comprising determining AV conduction time is higher than 250 ms.

8. The method of claim 7 further comprising:

determining AV block III is present in the patient; and

delivering the calcium channel blocker agent at a second dosage.

9. The method of claim 7 further comprising determining pacing is required.

10. The method of claim 1 wherein the catheter includes a fluid container for holding the calcium channel blocker agent, the fluid container having a distal tip for delivering the calcium channel blocker agent.

2. A method of treating atrial fibrillation in a patient, the method comprising:

delivering a catheter to AV nodal tissue of the patient;

fixating the catheter to the AV nodal tissue;

determining an occurrence of atrial fibrillation;

delivering a calcium channel blocker agent into the AV nodal tissue to increase AV nodal tissue refractoriness and decrease ventricular rate upon determining the occurrence of atrial fibrillation;

monitoring an electrical response by the heart to the calcium channel blocker agent via a closed loop system, wherein the electrical response comprises at least AV conduction time; and

adjusting quantity of the delivered calcium channel blocker agent using the closed loop system based at least on AV conduction time,

wherein the AV nodal tissue is within a triangle of Koch.

11. A method of treating atrial fibrillation in a patient, the method comprising:

delivering a catheter to AV nodal tissue of the patient, the catheter having a distal end;

penetrating the AV nodal tissue with the distal end of the catheter;

delivering a calcium channel blocker agent into the AV nodal tissue through the catheter to increase AV nodal tissue refractoriness and decrease ventricular rate;

monitoring an electrical response by the heart to the calcium channel blocker agent via a closed loop system, wherein the electrical response comprises at least AV conduction time; and

adjusting quantity of the delivered calcium channel blocker agent using the closed loop system based at least on AV conduction time.

12. A method of treating atrial fibrillation in a patient, the method comprising:

delivering a catheter to AV nodal tissue of the patient, the catheter having a distal end;

penetrating the AV nodal tissue with the distal end of the catheter;

delivering an agent into the AV nodal tissue through the catheter to increase AV nodal tissue refractoriness and decrease ventricular rate;

monitoring an electrical response by the heart to the agent via a closed loop system, wherein the electrical response comprises at least AV conduction time; and

adjusting quantity of the delivered agent using the closed loop system based at least on AV conduction time.

13. A method of treating atrial fibrillation in a patient, the method comprising:

delivering a catheter to a triangle of Koch of the patient;

penetrating the triangle of Koch with a distal end of the catheter;

delivering a calcium channel blocker agent through the catheter into the triangle of Koch to increase AV nodal tissue refractoriness and decrease ventricular rate; and

monitoring an electrical response by the heart to the calcium channel blocker agent via a closed loop system, wherein the electrical response comprises at least AV conduction time, and

adjusting quantity of the delivered calcium channel blocker agent using the closed loop system based at least on AV conduction time.