Systems and methods for stimulating tissue using focused energy

• US 8,892,200 B2
• Filed: 06/27/2011
• Issued: 11/18/2014
• Est. Priority Date: 06/19/2006
• Status: Active Grant

• Current Assignee: Highland Instruments, Inc.,
• Original Assignee: Highland Instruments, Inc.,
• Inventors: Wagner, Timothy A., Eden, Uri T.
• Primary Examiner(s): BOCKELMAN, MARK
• Application Number:
  US13/169,288
• Publication Number:
  US 20110275963A1
• Time in Patent Office: 1,240 Days
• Field of Search: 601 2- 3, 607/3, 607/45
• US Class Current: 607/3
• CPC Class Codes: A61N 1/0408 Use-related aspects
• CPC Class Codes: A61N 1/0452 Specially adapted for transcutaneous muscle stimulation [TMS]
• CPC Class Codes: A61N 1/0456 Specially adapted for transcutaneous electrical nerve stimulation [TENS]
• CPC Class Codes: A61N 1/0484 Garment electrodes worn by the patient
• CPC Class Codes: A61N 1/0529 Electrodes for brain stimulation
• CPC Class Codes: A61N 1/36025 for treating a mental or cerebral condition
• CPC Class Codes: A61N 1/36071 Pain
• CPC Class Codes: A61N 1/36082 Cognitive or psychiatric applications, e.g. dementia or Alzheimer's disease
• CPC Class Codes: A61N 1/36182 Direction of the electrical field, e.g. with sleeve around stimulating electrode
• CPC Class Codes: A61N 1/40 Applying electric fields by inductive or capacitive coupling microwave apparatus A61N5/00; Applying radio-frequency signals

Abstract

The present invention generally relates to systems and methods for stimulating tissue using focused energy. In certain embodiments, the invention provides a system for stimulating tissue that includes a first energy source, a second energy source, and a focusing element that focuses at least the first or second energy source so that the first and second energy sources target the same region of tissue such that the combined effect stimulates the tissue.

Claims

1. A method for stimulating neural tissue beneath skin of a patient to treat an ailment, the method comprising:

noninvasively providing a mechanical field transcranially to a region of neural tissue beneath skin;

noninvasively providing an AC electric field of less than 100,000 Hz transcranially to the region of neural tissue beneath skin, wherein the AC field is generated by one or more external electrodes; and

focusing at least the mechanical field or the electric field so that the mechanical field and the electric field target the same region of neural tissue beneath skin, wherein the combined effect stimulates the neural tissue beneath skin providing a treatment that affects the ailment.

2. The method according to claim 1, wherein the mechanical field is generated by an ultrasound device.

3. The method according to claim 1, wherein the mechanical field is pulsed.

4. The method according to claim 1, wherein the mechanical field is time varying.

5. The method according to claim 1, wherein the mechanical field is pulsed a plurality of time, and each pulse may be for a different length of time.

6. The method according to claim 1, wherein the electric field is pulsed.

7. The method according to claim 1, wherein the electric field is time varying.

8. The method according to claim 1, wherein the electric field is pulsed a plurality of time, and each pulse may be for a different length of time.

9. The method according to claim 1, wherein the electric field is time invariant.

10. The method according to claim 1, wherein the first and second types of energy are applied to a structure or multiple structures within the brain or the nervous system selected from the group consisting of:

dorsal lateral prefrontal cortex, any component of the basal ganglia, nucleus accumbens, gastric nuclei, brainstem, thalamus, inferior colliculus, superior colliculus, periaqueductal gray, primary motor cortex, supplementary motor cortex, occipital lobe, Brodmann areas 1-48, primary sensory cortex, primary visual cortex, primary auditory cortex, amygdala, hippocampus, cochlea, cranial nerves, cerebellum, frontal lobe, occipital lobe, temporal lobe, parietal lobe, sub-cortical structures, and spinal cord.

11. The method according to claim 1, wherein the effect of the stimulation alters neural function past the duration of stimulation.