Implantable MEMs intraocular pressure sensor devices and methods for glaucoma monitoring

• US 8,894,578 B2
• Filed: 03/07/2012
• Issued: 11/25/2014
• Est. Priority Date: 09/18/2009
• Status: Active Grant

• Current Assignee: Orthomems, Inc.
• Original Assignee: Orthomems, Inc.
• Inventors: Wong, Vernon G., Lee, Douglas A.
• Primary Examiner(s): Dougherty, Sean
• Assistant Examiner(s): CERIONI, DANIEL LEE
• Application Number:
  US13/414,069
• Publication Number:
  US 20120226133A1
• Time in Patent Office: 993 Days
• Field of Search: 600/398, 600/399
• US Class Current: 600/398
• CPC Class Codes: A61B 2562/028 Microscale sensors, e.g. electromechanical sensors [MEMS]
• CPC Class Codes: A61B 3/16 for measuring intraocular pressure, e.g. tonometers
• CPC Class Codes: A61B 5/6846 specially adapted to be brought in contact with an internal body part, i.e. invasive

Abstract

An implantable device for measuring IOP comprises a distal portion, a proximal portion and a conformable elongate support extending between the distal and proximal portions. The distal portion comprises a pressure sensor, for example a capacitor, and the proximal portion comprises a coil. The conformable elongate support extends between the distal portion and the coil so as to couple the distal portion to the coil, and the conformable elongate support is sized to position the sensor in the anterior chamber when the proximal portion is positioned under a conjunctiva of the eye. Positioning of the pressure sensor in the anterior chamber has the benefit of readily accessible surgical access and a direct measurement of the IOP of the eye. The proximal portion comprising the coil can be configured to place the coil between the sclera and the conjunctiva, such that the invasiveness of the surgery can be decreased substantially.

Claims

1. An implantable device for measuring an intraocular pressure of an eye having an anterior chamber and a conjunctiva, the implantable device comprising:

a distal portion comprising a pressure sensor,

a proximal portion comprising a coil; and

a conformable elongate support extending between the distal portion and the coil to couple the distal portion to the coil and wherein the conformable elongate support is sized to position the sensor in the anterior chamber when the proximal portion is positioned under a conjunctiva of the eye,

wherein the pressure sensor comprises a pressure transducer for placement in the anterior chamber and responsive to pressure of the anterior chamber and comprises a compliant enclosure encapsulating the pressure sensor,

wherein the compliant enclosure is filled with a conformable material comprising one or more of a liquid, viscous material, or gel and the compliant enclosure is configured to be positioned in the anterior chamber such that the conformable material transmits pressure exerted on the compliant enclosure to the pressure transducer, and

wherein the conformable material is positioned over the pressure transducer such that pressure exerted on the compliant enclosure in any direction is exerted uniformly on one or more of a first side or a second side of the pressure sensor.

2. The implantable device of claim 1, wherein the pressure sensor comprises a capacitor responsive to the intraocular pressure, the capacitor having a first side and a second side, and wherein the conformable material is disposed over the first side and the second side such that the capacitive sensor is responsive to pressure on each of the first side and the second side when positioned in the anterior chamber.

3. The implantable device of claim 2, wherein the capacitor is encapsulated with the conformable material.

4. The implantable device of claim 2, wherein the distal portion comprises a maximum cross-sectional size of no more than about 0.5 mm.

5. The implantable device of claim 1, wherein the proximal portion comprises a coil coupled to the pressure sensor such that the coil is positioned under the conjunctiva when the distal portion is positioned in the aqueous humor.

6. The implantable device of claim 5, wherein the coil comprises a substantially single loop antenna coil coupled to a second coil having a plurality of turns.

7. The implantable device of claim 5, wherein the coil is disposed on a substrate and wherein the substrate comprises a curved shape so as to conform to a curvature of the eye.

8. The implantable device of claim 7, wherein the proximal portion comprises a lower concave surface to contact a sclera of the eye and an upper convex surface to contact the conjunctiva of the eye such that the upper convex surface and the lower concave surface correspond to the curvature of the eye when the distal portion is inserted into the anterior chamber.

9. The implantable device of claim 8, wherein the upper convex surface has a curvature corresponding substantially to the curvature of the eye and wherein the lower concave surface has the curvature corresponding substantially to the curvature of eye, such that the proximal portion is retained between the sclera and the conjunctiva with the conjunctiva extending over the upper surface when the distal portion is positioned in the anterior chamber.

10. The implantable device of claim 5, wherein the coil is joined to the pressure sensor with the conformable material further extending between the coil and the pressure sensor.

11. The implantable device of claim 5, wherein the coil is attached to the pressure sensor with the conformable material extending between the coil and the pressure sensor.

12. The implantable device of claim 5, wherein the proximal portion comprises a maximum distance across of no more than about 15 mm.

13. The implantable device of claim 5, wherein the proximal portion comprises a maximum distance across of no more than about 10 mm.

14. The implantable device of claim 5, wherein the proximal portion comprises a maximum distance across of no more than about 6 mm.

15. The implantable device of claim 5, wherein the proximal portion comprises a maximum thickness across of no more than about 1 mm.

16. The implantable device of claim 5, wherein the proximal portion comprises a maximum thickness of no more than about 0.5 mm.

17. The implantable device of claim 1, wherein the distal portion comprises a maximum thickness of no more than about 0.5 mm.

18. The implantable device of claim 1, wherein the conformable elongate support comprises an intermediate portion having a length of no more than about 10 mm.

19. The implantable device of claim 1, wherein the conformable elongate support comprises an intermediate portion having a cross sectional size within a range from about 1 to 3 French.

20. The implantable device of claim 1, wherein the conformable elongate support comprises an intermediate portion having a conformable tube extending between the proximal portion and the distal portion and wherein the tube is disposed over a conformable conductor and substrate extending from the pressure sensor to the proximal portion.

21. The implantable device of claim 1, wherein the pressure sensor and the coil are disposed on a substrate such that the coil is coupled to the sensor with the substrate and wherein the conformable elongate support comprises an intermediate portion of the substrate disposed between the proximal portion and the distal portion and wherein the intermediate portion of the substrate is composed of a material having a thickness and a width such that the intermediate portion is capable of conforming to the eye.