Optical pulse-width modulation used in an optical-stimulation cochlear implant

• US 8,894,697 B2
• Filed: 07/21/2012
• Issued: 11/25/2014
• Est. Priority Date: 07/22/2011
• Status: Active Grant

• Current Assignee: Nurotone Medical Ltd.
• Original Assignee: Lockheed Martin Corporation (Martin Marietta Corporation)
• Inventors: Stafford, Ryan C., Stafford, James W., Norton, Bryan J.
• Primary Examiner(s): Crandall, Lynsey
• Assistant Examiner(s): PAHAKIS, MANOLIS Y
• Application Number:
  US13/555,097
• Publication Number:
  US 20130023964A1
• Time in Patent Office: 857 Days
• Field of Search: None
• US Class Current: 607/89
• CPC Class Codes: A61N 1/0541 Cochlear electrodes
• CPC Class Codes: A61N 1/36039 fitting procedures
• CPC Class Codes: A61N 2005/0605 Ear
• CPC Class Codes: A61N 2005/0626 Monitoring, verifying, controlling systems and methods
• CPC Class Codes: A61N 2005/0652 Arrays of diodes
• CPC Class Codes: A61N 2005/0659 infrared
• CPC Class Codes: A61N 5/0622 Optical stimulation for exciting neural tissue
• CPC Class Codes: A61N 5/067 using laser light
• CPC Class Codes: F04C 2270/0421 Controlled or regulated

Abstract

Method and apparatus for optically stimulating neurons of a plurality of auditory nerve pathways of a person to provide auditory sensations for the person including generating a plurality of pulsed light signals having one or more successive pulses; delivering the plurality of pulsed light signals to one or more auditory nerve pathways of the cochlea of the person; selectively controlling the plurality of light signals to optically stimulate and trigger nerve action potentials (NAPs) in the one or more auditory nerve pathways. In some embodiments of the present invention, pulse-repetition rate and peak pulse power are held constant, while pulse width is modulated to evoke a sufficient dynamic range of NAPs (i.e., different NAP strengths), thus encoding sound-loudness information for the listener.

Claims

1. An apparatus for optically stimulating neurons of a cochlea of a person to provide sound-perception auditory sensations for the person, the apparatus comprising:

means for sensing an audio signal in real time;

means for extracting real time audio signal strength from the audio signal;

means for generating a plurality of pulsed light signals having a pulse repetition rate, a peak power, and a pulse width, the plurality of pulsed light signals further having a plurality of one or more successive pulses, each capable of stimulating a nerve action potential (NAP) in the neuron of the person;

means for delivering the plurality of light signals to a plurality of locations in the cochlea of the person; and

means for selectively controlling the plurality of light signals output by the means for generating to optically stimulate one or more neurons in the cochlea in order to trigger NAPs in the one or more neurons of the cochlea, wherein the means for selectively controlling the plurality of pulsed light signals is configured to hold constant the pulse repetition rate and the peak power of the plurality of pulsed light signals and, concurrently, to modulate the pulse width of the plurality of pulsed light signals in response to the real time audio signal strength so as to encode a dynamic range of sound loudness for the person in real time.

2. The apparatus of claim 1, wherein the means for selectively controlling includes means for empirically testing the delivering of the plurality of light signals and means for determining of a pulse width range of the plurality of light signals that is most effective for encoding the dynamic range of sound loudness for the person, and means for using results from the means for testing to control the means for delivering to deliver light signals having pulse width the pulse width range that was determined to be most effective for encoding dynamic range of sound loudness for the person.

3. The apparatus of claim 1, wherein the means for selectively controlling includes means for empirically testing the delivering of the plurality of light signals and means for determining one light signal pulse repetition rate and one peak power value of the plurality of light signals that are most effective for optically stimulating the one or more neuron of the cochlea.

4. The apparatus of claim 1, wherein the means for selectively controlling includes means for determining one or more ranges of pulse width of the plurality of light signals that is most effective for encoding the dynamic range of sound loudness information for the person.

5. The apparatus of claim 1, wherein the means for selectively controlling includes means for determining one or more temporal shapes of pulses of the plurality of light signals that is most effective for encoding the dynamic range of sound loudness information for the person.

6. The apparatus of claim 1, wherein the pulse width is no more than 100 microseconds.

7. The apparatus of claim 1,

means for determining whether the audio signal is spoken human voice or music;

means for selecting a first pulse repetition rate, a first peak power of the plurality of light signals and a first pulse width range to improve voice perception in the person when the audio signal is spoken human voice; and

means for selecting a second pulse repetition rate, a second peak power of the plurality of light signals and a second pulse width range to improve music perception in the person when the audio signal is music.

8. The apparatus of claim 1, wherein the means for generating the plurality of pulsed light signals includes a plurality of vertical-cavity-surface-emitting laser (VCSEL) arrays including a first VCSEL array and a second VCSEL array.

9. The apparatus of claim 1, wherein the means for selectively controlling controls the means for generating the plurality of light signals such that an intensity profile of each of the plurality of successive pulses of the plurality of light signals is constant, and wherein the means for selectively controlling includes means for determining one or more ranges of pulse width of the plurality of light signals that is most effective for encoding the dynamic range of sound loudness information for the person.

10. The apparatus of claim 1, wherein the means for selectively controlling controls the means for generating the plurality of light signals such that an spatial intensity of each of the plurality of successive pulses of the plurality of light signals is varied, and wherein the means for selectively controlling includes means for determining one or more ranges of pulse width of the plurality of light signals that is most effective for encoding the sound-loudness information for the person.

11. The apparatus of claim 1, wherein the means for generating the plurality of pulsed light signals includes a plurality of vertical-cavity-surface-emitting lasers (VCSELs) including a first VCSEL and a second VCSEL, and wherein the means for selectively controlling controls the means for generating the plurality of light signals such that the first VCSEL provides a first portion of each of the plurality of successive pulses of the plurality of light signals and such that the second VCSEL provides a second portion of each of the plurality of successive pulses of the plurality of light signals.

12. An apparatus for optically stimulating neurons of a cochlea of a person to provide sound-perception auditory sensations for the person, the apparatus comprising:

an audio sensor configured to sense an audio signal in real time;

an audio processor configured to extract real time audio signal strength from the audio signal;

an optical generator configured to output a plurality of pulsed light signals having a pulse repetition rate, a peak power, and a pulse width, the plurality of pulsed light signals further having one or more successive pulses, each capable of stimulating a nerve action potential (NAP) in the neuron of the person;

an optical guide configured to deliver the plurality of light signals to a plurality of locations in the cochlea of the person; and

a controller configured to control the plurality of light signals output by the optical generator to optically stimulate one or more neurons in the cochlea in order to trigger NAPs in the one or more neurons of the cochlea, wherein the controller is further configured to hold constant the pulse repetition rate and the peak power of the plurality of pulsed light signals and, concurrently, to modulate the pulse width of the plurality of pulsed light signals in response to the real time audio signal strength so as to encode a dynamic range of sound loudness for the person in real time.

13. The apparatus of claim 12, wherein the controller is further configured to empirically test the delivery of the plurality of light signals to determine a pulse width range of the plurality of light signals that is most effective for encoding the dynamic range of sound loudness for the person, and to use results of the test such that the delivered light signals have the pulse width range that was determined to be most effective for optically encoding the dynamic range of sound loudness for the person.

14. The apparatus of claim 12, wherein the controller is further configured to empirically test the delivery of the plurality of light signals and to determine one pulse repetition rate and one peak power of the plurality of light signals that are most effective for optically stimulating the one or more neurons of the cochlea.

15. The apparatus of claim 12, wherein the controller is further configured to determine one or more ranges of pulse width of the plurality of light signals that is most effective for encoding the dynamic range of sound loudness information for the person.

16. The apparatus of claim 12, wherein the controller is further configured to determine one or more temporal shapes of pulses of the plurality of light signals that is most effective for encoding the dynamic range of sound loudness information for the person.

17. The apparatus of claim 12,

wherein the audio processor is further configured to:

determine whether the audio signal is spoken human voice or music,

select a first pulse repetition rate, a first peak power of the plurality of light signals and a first pulse width range to improve voice perception in the person when the audio signal is spoken human voice, and

select a second pulse repetition rate, a second peak power of the plurality of light signals and a second pulse width range to improve music perception in the person when the audio signal is music.

18. The apparatus of claim 12, wherein the pulse width is no more than 100 microseconds.

19. The apparatus of claim 12, wherein the controller is further configured to control the optical generator such that an intensity profile of each of the one or more successive pulses of the plurality of light signals is constant, and wherein the controller is further configured to determine one or more ranges of pulse width of the plurality of light signals that is most effective for encoding the dynamic range of sound loudness information for the person.

20. The apparatus of claim 12, wherein the optical generator includes a plurality of vertical-cavity-surface-emitting lasers (VCSELs) including a first VCSEL and a second VCSEL, and wherein the controller is further configured to control the optical generator such that the first VCSEL provides a first portion of each of the one or more successive pulses of the plurality of light signals and such that the second VCSEL provides a second portion of each of the one or more successive pulses of the plurality of light signals.

21. The apparatus of claim 12, wherein the optical generator includes a plurality of vertical-cavity-surface-emitting laser (VCSEL) arrays including a first VCSEL array and a second VCSEL array.