Radiopharmaceuticals for diagnosis and therapy
First Claim
1. A method comprising:
- administering respective radiolabeled forms of a plurality of therapeutic agents to a patient, wherein two or more of the radiolabeled forms of the plurality of therapeutic agents are radiolabeled with a same radiotracer;
determining information related to respective biodistributions of the respective radiolabeled forms of the plurality of therapeutic agents in the patient by performing simultaneous functional imaging of the respective radiolabeled forms of the plurality of therapeutic agents during a radioimaging procedure on the patient after administering the respective radiolabeled forms of the plurality of therapeutic agents, wherein performing simultaneous functional imaging of the respective radiolabeled forms of the plurality of therapeutic agents comprises analyzing differing kinetics of the respective radiolabeled forms of the plurality of therapeutic agents; and
treating the patient by administering the one or more of the plurality of therapeutic agents to the patient at respective therapeutically-effective doses and withholding administering at least one other of the plurality of therapeutic agents.
6 Assignments
0 Petitions
Accused Products
Abstract
A method for treating a human patient is provided, including administering a radiolabeled form of a therapeutic agent to the patient at a first substantially non-therapeutically-effective dose, wherein pharmacological activity of the therapeutic agent is not due to radioactivity of the therapeutic agent. The method also includes determining information related to a biodistribution of the radiolabeled form of the therapeutic agent in the patient by performing a radioimaging procedure on the patient. Responsively to the information, a decision is made whether or not to treat the patient by administering the therapeutic agent to the patient. If the decision is made to treat the patient, the patient is treated by administering the therapeutic agent to the patient at a second therapeutically-effective dose. If the decision is made not to treat the patient, treatment of the patient with the therapeutic agent is withheld. Other embodiments are also described.
781 Citations
21 Claims
-
1. A method comprising:
-
administering respective radiolabeled forms of a plurality of therapeutic agents to a patient, wherein two or more of the radiolabeled forms of the plurality of therapeutic agents are radiolabeled with a same radiotracer; determining information related to respective biodistributions of the respective radiolabeled forms of the plurality of therapeutic agents in the patient by performing simultaneous functional imaging of the respective radiolabeled forms of the plurality of therapeutic agents during a radioimaging procedure on the patient after administering the respective radiolabeled forms of the plurality of therapeutic agents, wherein performing simultaneous functional imaging of the respective radiolabeled forms of the plurality of therapeutic agents comprises analyzing differing kinetics of the respective radiolabeled forms of the plurality of therapeutic agents; and treating the patient by administering the one or more of the plurality of therapeutic agents to the patient at respective therapeutically-effective doses and withholding administering at least one other of the plurality of therapeutic agents. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21)
-
Specification