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Combination of local temozolomide with local BCNU

  • US 8,895,597 B2
  • Filed: 06/17/2011
  • Issued: 11/25/2014
  • Est. Priority Date: 06/17/2010
  • Status: Active Grant
First Claim
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1. A composition for treating an individual with a solid tumor comprising a combination of carmustine and temozolomidein a pharmaceutically acceptable polymeric carrier for sustained local administration of an effective amount of the carmustine and temozolomide to reduce tumor size or prolong survival of the individual with greater efficacy or reduced systemic side effects as compared to administration of either carmustine or temozolomide systemically.

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