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Composition and method for treating neurological disease

DC
  • US 8,895,617 B1
  • Filed: 08/04/2014
  • Issued: 11/25/2014
  • Est. Priority Date: 11/24/2004
  • Status: Active Grant
First Claim
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1. A method comprising:

  • orally administering to a human subject with Parkinson'"'"'s disease a once-daily dose consisting of (i) 200 mg to 500 mg of a drug selected from the group consisting of amantadine and pharmaceutically acceptable salts thereof, and (ii) at least one excipient, wherein the drug in the dose comprises an extended release form, and wherein the extended release form of the drug in the dose provides a mean change in amantadine plasma concentration as a function of time (dC/dT) that is less than 40% of the dC/dT provided by the same quantity of the drug in an immediate release form, wherein the dC/dT values are measured in a single dose human pharmacokinetic study over the time period between 0 and 4 hours after administration.

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