Devices and methods for detecting an analyte in salivary fluid
First Claim
1. A system for detecting one or more analyte in salivary fluid, comprising:
- a discrete oral component configured for complete enclosure in a human oral cavity without protrusion therefrom or attachment thereto, the discrete oral component configured to release at least one medicinal agent responsive to the presence of a substance in the salivary fluid;
at least one sensor incorporated within the discrete oral component and configured for removal therefrom, wherein the sensor specifically identifies the one or more analyte in the salivary fluid and generates a signal that the identification has been made; and
an external device including a port including a cavity configured for physical contact with the discrete oral component and including one or more devices for detection of the signal from the sensor.
3 Assignments
0 Petitions
Accused Products
Abstract
Methods and systems are described herein for detecting one or more analyte in salivary fluid. Systems include: a discrete oral component configured for complete enclosure in a human oral cavity; at least one sensor configured to detect one or more analyte in salivary fluid; and an external device including a port configured for communication with the discrete oral component. Methods include: detecting one or more analyte within salivary fluid with at least one sensor integral to a discrete oral component, wherein the discrete oral component is configured to be completely enclosed in the oral cavity and includes one or more flavorant; and communicating information from the discrete oral component to at least one external device.
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Citations
40 Claims
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1. A system for detecting one or more analyte in salivary fluid, comprising:
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a discrete oral component configured for complete enclosure in a human oral cavity without protrusion therefrom or attachment thereto, the discrete oral component configured to release at least one medicinal agent responsive to the presence of a substance in the salivary fluid; at least one sensor incorporated within the discrete oral component and configured for removal therefrom, wherein the sensor specifically identifies the one or more analyte in the salivary fluid and generates a signal that the identification has been made; and an external device including a port including a cavity configured for physical contact with the discrete oral component and including one or more devices for detection of the signal from the sensor. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. A method for detecting one or more analyte in salivary fluid comprising:
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swallowable positioning a discrete oral component within an oral cavity, wherein the discrete oral component is configured to be completely enclosed in the oral cavity without protrusion therefrom or attachment thereto and includes one or more flavorant; identifying the one or more analyte in salivary fluid with at least one sensor integral to the discrete oral component; generating a first signal from the at least one sensor that the one or more analyte has been identified; detecting the first signal from the at least one sensor with at least one external device; releasing one or more agent responsive to the use of the discrete oral component; identifying the one or more agent or a metabolite of the one or more agent in the salivary fluid with the at least one sensor; generating a second signal from the at least one sensor that the one or more agent or the metabolite of the one or more agent has been identified; and detecting the second signal from the at least one sensor with the at least one external device. - View Dependent Claims (19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35)
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36. A method for providing information relating to a health history for at least one individual comprising:
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swallowable positioning a discrete oral component within a human oral cavity, wherein the discrete oral component is configured to be completely enclosed in the human oral cavity without protrusion therefrom or attachment thereto and includes one or more flavorant; sampling salivary fluid at a first time point from the at least one individual utilizing the discrete oral component, the discrete oral component further including at least one diagnostic agent configured for release during use of the discrete oral component; releasing the at least one diagnostic agent from the discrete oral component at the first time point; identifying, with at least one sensor incorporated within the discrete oral component, one or more analyte in the salivary fluid from the at least one individual at the first time point; generating a first signal from the at least one sensor, wherein the first signal is generated as a consequence of the identification of the one or more analyte; identifying, with the at least one sensor, the at least one diagnostic agent or a metabolite of the at least one diagnostic agent in the salivary fluid from the at least one individual at a second time point; generating a second signal from the at least one sensor, wherein the second signal is generated responsive to the identification of the at least one diagnostic agent or a metabolite of the at least one diagnostic agent in the salivary fluid; detecting the first signal and the second signal with an external device including a port including a cavity configured for physical contact with the discrete oral component and including one or more devices for detection of the signal from the sensor; processing, in the external device, the first signal from the at least one sensor into at least one first result and the second signal from the at least one sensor into at least one second result; storing the at least one first result and the at least one second result integrated into the health history for the at least one individual in memory; and indicating the at least one first result and the at least one second result to at least one system user. - View Dependent Claims (37, 38)
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39. A system for detecting one or more analyte in salivary fluid, comprising:
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a discrete oral component configured for complete enclosure in a human oral cavity without protrusion, the discrete oral component including a shell with a permeable area and a removable module therein; at least one sensor configured to sense the one or more analyte in salivary fluid, the at least one sensor incorporated within the removable module, the at least one sensor including a reversibly antigen-responsive hydrogel core and at least one type of antibody corresponding to a viral protein; and an external device including a port configured for size measurement of the removable module, the port including a cavity configured for physical contact with the discrete oral component.
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40. A system for detecting one or more analyte in salivary fluid, comprising:
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a discrete oral component configured for complete enclosure in a human oral cavity without protrusion therefrom or attachment thereto, the discrete oral component including a shell, the shell including a permeable area having an outermost porous covering and a selective medium internal to the shell, the discrete oral component configured to release at least one medicinal agent responsive to a substance in the salivary fluid; at least one sensor configured to; identify the one or more analyte in the salivary fluid; generate a first signal indicative of the identification of the one or more analyte; identify the at least one medicinal agent in the salivary fluid or a metabolite of the at least one medicinal agent in the salivary fluid; and generate a second signal indicative of the identification of the at least one medicinal agent or the metabolite of the at least one medicinal agent in the salivary fluid; and an external device including at least one device configured to detect the first and the second signals from the at least one sensor, and including a port with a cavity configured for physical contact with the discrete oral component.
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Specification