Microneedle devices and microneedle delivery apparatus
First Claim
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1. An article comprising:
- a microneedle device comprising;
a substrate comprising a first major surface; and
at least one microneedle projecting from the first major surface of the substrate, the at least one microneedle comprising a base proximate the first major surface of the substrate, wherein the at least one microneedle is tapered from the base to a flat tip distal from the base such that the at least one microneedle comprises a truncated tapered shape;
wherein the flat tip comprises a surface comprising a surface area measured in a plane aligned with the base of 20 square micrometers or more and 250 square micrometers or less, wherein the surface does not include an opening.
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Abstract
Microneedle devices with microneedles having a truncated tapered shape are disclosed. The microneedles of microneedle devices may also have a controlled aspect ratio. Microneedle delivery apparatus are disclosed that include drivers designed to deliver microneedles at velocities that may enhance perforation of the stratum corneum while limiting the sensation of pain experienced at the delivery site.
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Citations
17 Claims
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1. An article comprising:
a microneedle device comprising; a substrate comprising a first major surface; and at least one microneedle projecting from the first major surface of the substrate, the at least one microneedle comprising a base proximate the first major surface of the substrate, wherein the at least one microneedle is tapered from the base to a flat tip distal from the base such that the at least one microneedle comprises a truncated tapered shape; wherein the flat tip comprises a surface comprising a surface area measured in a plane aligned with the base of 20 square micrometers or more and 250 square micrometers or less, wherein the surface does not include an opening. - View Dependent Claims (2, 3, 4, 5, 6, 7, 9, 10, 11, 12)
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8. An article comprising:
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a microneedle device comprising; a substrate comprising a first major surface; and a plurality of microneedles projecting from the first major surface of the substrate, each microneedle of the plurality of microneedles comprising a base proximate the first major surface of the substrate, wherein each microneedle of the plurality of microneedles is formed of one or more polymers and is tapered from the base to a flat tip distal from the base such that each microneedle of the plurality of microneedles comprises a truncated tapered shape; wherein the flat tip comprises a surface comprising a surface area measured in a plane aligned with the base of 20 square micrometers or more and 100 square micrometers or less, wherein the surface does not include an opening; wherein the base of each microneedle of the plurality of microneedles comprises a base area of 900 square micrometers or more; and wherein each microneedle of the plurality of microneedles comprises a height above the first major surface and a maximum base dimension, the height and the maximum base dimension ratio defining an aspect ratio, wherein the aspect ratio is 3;
1 or more; anda microneedle delivery apparatus capable of accelerating at a velocity of 2m/s or more (a) the microneedle device or (b) a piston that impacts the microneedle device.
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13. A microneedle device comprising:
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a substrate comprising a first major surface; and at least one microneedle projecting from the first major surface of the substrate, the at least one microneedle comprising a base proximate the first major surface of the substrate, wherein the at least one microneedle is tapered from the base to a flat tip distal from the base such that the at least one microneedle comprises a truncated tapered shape; wherein the flat tip comprises a surface area measured in a plane aligned with the base of 20 square micrometers or more and 250 square micrometers or less. - View Dependent Claims (14, 15, 16, 17)
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Specification