Analyte sensor
First Claim
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1. An analyte sensor system comprising:
- a glucose sensor comprising;
at least one electrode having an electroactive surface;
optionally an interference layer in contact with at least a portion of the electroactive surface; and
an enzyme layer comprising a hydrophilic polymer-enzyme composition, at least a portion of the enzyme layer covering the electroactive surface, the enzyme layer providing an electrochemically detectable species capable of providing a detectable output;
wherein sensor break-in is about 30 minutes or less immediately following deployment;
wherein the hydrophilic polymer of the hydrophilic polymer-enzyme composition comprises a material selected from the group consisting of poly-N-vinylpyrrolidone, poly-N-vinyl-3-ethyl-2-pyrrolidone, poly-N-vinyl-4,5-dimethyl-2-pyrrolidone, polyvinylimidazole, poly-N—
N-dimethylacrylamide, polyacrylamide, and copolymers thereof; and
a catheter configured to be inserted into a vascular system of a subject, the catheter having an outer wall and comprising one or more ports formed in the outer wall;
wherein the sensor is positioned at the one or more of the ports.
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Abstract
Electrochemical sensors for measuring an analyte in a subject are described. More particularly, devices for measurement of an analyte incorporating a sensor comprising a hydrophilic polymer-enzyme composition covering an electroactive surface providing rapid and accurate analyte levels upon deployment are disclosed.
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Citations
18 Claims
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1. An analyte sensor system comprising:
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a glucose sensor comprising; at least one electrode having an electroactive surface; optionally an interference layer in contact with at least a portion of the electroactive surface; and an enzyme layer comprising a hydrophilic polymer-enzyme composition, at least a portion of the enzyme layer covering the electroactive surface, the enzyme layer providing an electrochemically detectable species capable of providing a detectable output;
wherein sensor break-in is about 30 minutes or less immediately following deployment;wherein the hydrophilic polymer of the hydrophilic polymer-enzyme composition comprises a material selected from the group consisting of poly-N-vinylpyrrolidone, poly-N-vinyl-3-ethyl-2-pyrrolidone, poly-N-vinyl-4,5-dimethyl-2-pyrrolidone, polyvinylimidazole, poly-N—
N-dimethylacrylamide, polyacrylamide, and copolymers thereof; anda catheter configured to be inserted into a vascular system of a subject, the catheter having an outer wall and comprising one or more ports formed in the outer wall; wherein the sensor is positioned at the one or more of the ports. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17)
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18. An analyte sensor system comprising:
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a glucose sensor comprising; at least one electrode having an electroactive surface;
optionally an interference layer in contact with at least a portion of the electroactive surface; andan enzyme layer comprising a hydrophilic polymer-enzyme composition, at least a portion of the enzyme layer covering the electroactive surface, the enzyme layer providing an electrochemically detectable species capable of providing a detectable output;
wherein sensor break-in is about 30 minutes or less immediately following deploymentwherein the hydrophilic polymer of the hydrophilic polymer-enzyme composition comprises a material selected from the group consisting of poly-N-vinylpyrrolidone, poly-N-vinyl-3-ethyl-2-pyrrolidone, poly-N-vinyl-4,5-dimethyl-2-pyrrolidone, polyvinylimidazole, poly-N—
N-dimethylacrylamide, polyacrylamide, and copolymers thereof; anda catheter configured to be inserted into a vascular system of a subject, the catheter having an outer wall and comprising one or more ports formed in the outer wall; wherein the sensor is positioned at the one or more of the ports and wherein the sensor is; substantially absent a separate intervening hydrophilic layer between the electroactive surface and the hydrophilic polymer-enzyme composition; substantially absent a separate intervening electrolyte layer between the electroactive surface and the interference layer; and substantially absent a separate intervening electrolyte layer between the interference layer and the enzyme layer; wherein the sensor is substantially absent silicone polymers, polyurethane polymers, and their copolymers.
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Specification