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Analyte sensor

  • US 8,900,431 B2
  • Filed: 08/25/2009
  • Issued: 12/02/2014
  • Est. Priority Date: 08/27/2008
  • Status: Active Grant
First Claim
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1. An analyte sensor system comprising:

  • a glucose sensor comprising;

    at least one electrode having an electroactive surface;

    optionally an interference layer in contact with at least a portion of the electroactive surface; and

    an enzyme layer comprising a hydrophilic polymer-enzyme composition, at least a portion of the enzyme layer covering the electroactive surface, the enzyme layer providing an electrochemically detectable species capable of providing a detectable output;

    wherein sensor break-in is about 30 minutes or less immediately following deployment;

    wherein the hydrophilic polymer of the hydrophilic polymer-enzyme composition comprises a material selected from the group consisting of poly-N-vinylpyrrolidone, poly-N-vinyl-3-ethyl-2-pyrrolidone, poly-N-vinyl-4,5-dimethyl-2-pyrrolidone, polyvinylimidazole, poly-N—

    N-dimethylacrylamide, polyacrylamide, and copolymers thereof; and

    a catheter configured to be inserted into a vascular system of a subject, the catheter having an outer wall and comprising one or more ports formed in the outer wall;

    wherein the sensor is positioned at the one or more of the ports.

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