Drug-impregnated encasement
First Claim
1. A biologically-compatible sleeve comprising:
- a body made of a biologically-compatible, resorbable, material and defining an internal cavity configured to receive a medical implant, the body defining a plurality of apertures extending from the cavity through the body;
a first end openable for receiving the medical implant;
a second end which is closed for retaining the medical implant; and
a drug impregnated into the biologically-compatible, resorbable material;
wherein the biologically-compatible, resorbable, material is a non-woven resorbable sheet, wherein the resorbable sheet comprises a polymer.
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Accused Products
Abstract
A drug-impregnated sleeve for encasing a medical implant is provided. In one embodiment, the sleeve may include a body made of a biologically-compatible material that defines an internal cavity configured to receive the medical implant. In one embodiment, the biologically-compatible material is bioresorbable. The body may include a plurality of apertures, such as perforations or holes, extending from the cavity through the body. The sleeve may further include a first end, a second end, and a drug impregnated into the resorbable sheet. In one possible embodiment, the first end of the sleeve may be open for receiving the medical implant therethrough and the second end may be closed. The implant may be encased in the sleeve and implanted into a patient from which the drug is dispensed in vivo over time to tissue surrounding the implantation site. In one embodiment, the body is made from at least one sheet of a biologically-compatible material, hi one embodiment, the sleeve may be made in least in part from caprolactone to add stretchability to the sleeve.
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Citations
159 Claims
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1. A biologically-compatible sleeve comprising:
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a body made of a biologically-compatible, resorbable, material and defining an internal cavity configured to receive a medical implant, the body defining a plurality of apertures extending from the cavity through the body; a first end openable for receiving the medical implant; a second end which is closed for retaining the medical implant; and
a drug impregnated into the biologically-compatible, resorbable material;wherein the biologically-compatible, resorbable, material is a non-woven resorbable sheet, wherein the resorbable sheet comprises a polymer. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68)
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69. A drug-impregnated sleeve comprising:
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at least one bioresorbable sheet comprised of a biologically-compatible material wherein at least one drug is impregnated into the sheet, the sheet further comprising a plurality of apertures; the sheet folded to create a rolled edge, a pair of free edges opposite the rolled edge, a first end extending between the rolled edge and the pair of free edges, and a second end extending between the rolled edge and the pair of free edges opposite the first end; and a seam connecting the pair of free edges to one another and closing the second end, wherein the first end defines an opening configured for receiving a medical implant at least partially encased by the sleeve. - View Dependent Claims (70, 71)
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72. A method of forming a drug-impregnated sleeve comprising:
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providing at least one first generally flat sheet of a biologically-compatible material having at least one drug impregnated into the sheet; forming a plurality of apertures in the sheet; folding the sheet to form a rolled edge, an opposite free edge, a first open end, and a second open end opposite the first end; forming a seam along the free edge to close the free edge; and forming a seam along the second end to close the second end, wherein the seam forming steps for the free edge and second end may be performed in any order. - View Dependent Claims (73, 74)
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75. A biologically-compatible sleeve comprising:
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a sheet of a biologically-compatible, resorbable, material, the sheet being folded and including at least one pair of edges being fused along a seam to define an internal cavity configured to receive a medical implant, the sheet defining a plurality of apertures extending from the cavity through the sheet; a first end openable for receiving the medical implant; a second end; and a drug impregnated into the biologically-compatible, resorbable material; wherein the sheet includes two or more layers configured to release the drug at different rates; wherein the plurality of apertures have a combined open area that is about 10% to about 80% of a total surface area of the sheet.
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76. A biologically-compatible sleeve comprising:
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a sheet of a biologically-compatible, resorbable, material, the sheet being folded and including at least one pair of edges being fused along a seam to define an internal cavity configured to receive a medical implant, the sheet defining a plurality of apertures extending from the cavity through the sheet; a first end openable for receiving the medical implant; a second end; and a drug impregnated into the biologically-compatible, resorbable material; wherein the sheet includes two or more layers configured to degrade in vivo at different rates; wherein the plurality of apertures have a combined open area that is about 10% to about 80% of a total surface area of the sheet.
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77. A biologically-compatible sleeve comprising:
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a sheet of a biologically-compatible, resorbable, material comprising about 30% polycaprolactone and about 70% polyactic acid, the sheet being folded and including at least one pair of edges being fused along a seam to define an internal cavity configured to receive a medical implant, the sheet defining a plurality of apertures extending from the cavity through the sheet; a first end openable for receiving the medical implant; a second end; and a drug impregnated into the biologically-compatible, resorbable material.
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78. A biologically-compatible sleeve comprising:
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a sheet of a biologically-compatible, resorbable, material, the sheet being folded and including at least one pair of edges being fused along a seam to define an internal cavity configured to receive a medical implant, the sheet defining a plurality of apertures extending from the cavity through the sheet, the plurality of apertures have a combined open area that is about 20% of a total surface area of the sheet; a first end openable for receiving the medical implant; a second end; and a drug impregnated into the biologically-compatible, resorbable material.
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79. A biologically-compatible sleeve comprising:
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a sheet of a biologically-compatible, resorbable, material, the sheet being folded and including at least one pair of edges being fused along a seam to define an internal cavity configured to receive a medical implant, the sheet defining a plurality of apertures extending from the cavity through the sheet, the plurality of apertures each have a diameter of at least 1.5 mm; a first end openable for receiving the medical implant; a second end; and a drug impregnated into the biologically-compatible, resorbable material.
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80. A biologically-compatible sleeve comprising:
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a body made of a biologically-compatible, resorbable, material and defining an internal cavity configured to receive a medical implant, the body defining a plurality of apertures extending from the cavity through the body; a first end openable for receiving the medical implant; a second end which is closed for retaining the medical implant; and
a drug impregnated into the biologically-compatible, resorbable material;
wherein the sleeve includes a top and bottom, at least a portion of the top or bottom being substantially planar. - View Dependent Claims (81, 82, 83, 84, 85, 86, 87, 88, 89, 90)
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91. A biologically-compatible sleeve comprising:
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a body made of a biologically-compatible, resorbable, material and defining an internal cavity configured to receive a medical implant, the body defining a plurality of apertures extending from the cavity through the body; a first end openable for receiving the medical implant; a second end which is closed for retaining the medical implant; and
a drug impregnated into the biologically-compatible, resorbable material;wherein the sleeve includes a first edge having a seam closing the first edge and the second end includes a seam closing the second end. - View Dependent Claims (92, 93, 94, 95, 96, 97, 98, 99)
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100. A biologically-compatible sleeve comprising:
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a body made of a biologically-compatible, resorbable, material and defining an internal cavity configured to receive a medical implant, the body defining a plurality of apertures extending from the cavity through the body, wherein the plurality of apertures have a combined open area that is about 10% to about 80% of a total surface area of the sleeve; a first end openable for receiving the medical implant; a second end which is closed for retaining the medical implant; and a drug impregnated into the biologically-compatible, resorbable material. - View Dependent Claims (101, 102, 103, 104, 105, 106, 107, 108, 109, 110, 111, 112, 113, 114, 115, 116, 117, 118)
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119. A biologically-compatible sleeve comprising:
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a body made of a biologically-compatible, resorbable, material and defining an internal cavity configured to receive a medical implant, wherein the medical implant is an orthopedic implant, the body defining a plurality of apertures extending from the cavity through the body; a first end openable for receiving the orthopedic implant; a second end which is closed for retaining the orthopedic implant; and a drug impregnated into the biologically-compatible, resorbable material. - View Dependent Claims (120, 121, 122, 123, 124, 125, 126, 127, 128, 129, 130, 131, 132, 133, 134, 135, 136, 137, 138, 139, 140, 141, 142, 143, 144, 145, 146, 147, 148, 149, 150, 151, 152, 153, 154, 155, 156, 157, 158, 159)
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Specification