Multi-axis charged particle cancer therapy method and apparatus

• US 8,901,509 B2
• Filed: 05/21/2009
• Issued: 12/02/2014
• Est. Priority Date: 05/22/2008
• Status: Active Grant

• Current Assignee: Andrey Vladimirovich Balakin, Pavel Vladimirovich Balakin
• Original Assignee: Vladimir Yegorovich Balakin
• Inventors: Balakin, Vladimir Yegorovich
• Primary Examiner(s): Marmor, II, Charles A
• Assistant Examiner(s): Dorna, Carrie R
• Application Number:
  US12/994,120
• Publication Number:
  US 20110118531A1
• Time in Patent Office: 2,021 Days
• Field of Search: 600 1- 8, 250/396, 250/492.1, 250/492.3, 250/396.ML, 315/26, 315/62, 315/503, 315/504, 378/65, 378/68
• US Class Current: 250/396.R
• CPC Class Codes: A61B 6/4258 for detecting non x-ray radiation, e.g. gamma radiation A61B6/037 takes precedence
• CPC Class Codes: A61N 2005/1087 Ions; Protons
• CPC Class Codes: G21K 1/087 by electrical means
• CPC Class Codes: G21K 1/093 by magnetic means
• CPC Class Codes: G21K 1/14 using charge exchange devices, e.g. for neutralising or changing the sign of the electrical charges of beams producing or accelerating neutral particle beams H05H3/00
• CPC Class Codes: H05H 13/04 Synchrotrons
• CPC Class Codes: H05H 7/04 Magnet systems , e.g. undulators, wigglers free-electron laser H01S3/0903; Energisation thereof
• CPC Class Codes: H05H 7/08 Arrangements for injecting particles into orbits
• CPC Class Codes: H05H 7/10 Arrangements for ejecting particles from orbits

Abstract

The invention comprises a multi-axis charged particle irradiation method and apparatus. The multi-axis controls includes separate or independent control of one or more of horizontal position, vertical position, energy control, and intensity control of the charged particle irradiation beam. Optionally, the charged particle beam is additionally controlled in terms of timing. Timing is coordinated with patient respiration and/or patient rotational positioning. Combined, the system allows multi-axis and multi-field charged particle irradiation of tumors yielding precise and accurate irradiation dosages to a tumor with distribution of harmful proximal distal energy about the tumor.

Claims

1. A method for controlling charged particles, the charged particles used to irradiate a tumor of a patient, comprising the steps of:

extracting the charged particles from a synchrotron using an extraction foil; and

controlling the charged particles along multiple axes, said multiple axes comprising;

an energy; and

an intensity,

wherein said step of controlling said energy uses timing of transmission of the charged particles through said extraction foil, and

wherein said step of controlling said intensity uses current originating from said extraction foil, and

wherein both said step of controlling said energy and said step of controlling said intensity occur prior to the charged particles passing through a Lamberson extraction magnet in said synchrotron during said step of extracting.

2. The method of claim 1, further comprising the steps of:

accelerating the charged particles during an acceleration period of said synchrotron; and

timing extraction of the charged particles striking an extraction foil to yield said energy.

3. The method of claim 2, further comprising the steps of:

striking said extraction foil with the charged particles to yield a current;

using said current as a feedback control to a radio-frequency cavity system; and

controlling said intensity by applying a radio frequency in said feedback control to said radio-frequency cavity system.

4. The method of claim 3, wherein said step of controlling the charged particles along multiple axes further comprises the steps of:

controlling an x-axis position of the charged particles; and

controlling a y-axis position of the charged particles,

wherein said step of controlling the charged particles along multiple axes further comprises the step of delivering the charged particles at a set point in a breathing cycle of the patient at at least five rotation positions of a rotatable platform holding the patient.

5. The method of claim 1, wherein said synchrotron further comprises:

a beam extraction path, said beam extraction path sequentially comprising;

a radio-frequency cavity system comprising a first pair of blades;

said extraction foil comprising a thickness of about thirty to one-hundred microns, said extraction foil consisting essentially of atoms having six or fewer protons;

a second pair of blades; and

an extraction magnet.

6. The method of claim 5, further comprising the steps of:

applying a radio-frequency across said first pair of blades to yield altered trajectory charged particles;

passing the altered trajectory charged particles through said extraction foil yielding reduced energy charged particles;

transmitting the reduced energy charged particles through said second pair of blades;

applying a direct current voltage of at least five hundred volts across said second pair of blades; and

extracting the reduced energy charged particles out of said synchrotron using an extraction magnet.

7. The method of claim 5, further comprising the step of:

feedback controlling said intensity using a feedback control, said feedback control using a current generated by the charged particles transmitting through said extraction foil as an indicator of charged particle intensity.

8. The method of claim 7, further comprising the steps of:

rotating a rotatable platform through at least one hundred eighty degrees during an irradiation period of the patient; and

timing said step of controlling the charged particles along said multiple axes of said energy and said intensity in greater than four rotation positions of said rotatable platform.

9. The method of claim 8, further comprising the steps of:

generating a respiration signal with a respiration sensor, said respiration signal corresponding to a respiration cycle of the patient;

rotating a rotatable platform holding the patient, during use, through at least one hundred eighty degrees during an irradiation period of the patient,

timing said step of controlling the charged particles along multiple axes to correlate with said respiration signal, and

delivering the charged particles in greater than four rotation positions of said rotatable platform.

10. The method of claim 1, wherein said step of controlling the charged particles along multiple axes further comprises the step of:

controlling a magnetic field in a bending magnet of said synchrotron, said bending magnet comprising;

a tapered iron based core adjacent a gap, said core comprising a surface polish of less than 10 microns roughness; and

a focusing geometry comprising;

a first cross-sectional distance of said iron based core forming an edge of said gap,

a second cross-sectional distance of said iron based core not in contact with said gap, wherein said second cross-sectional distance is at least fifty percent larger than said first cross-sectional distance, said first cross-sectional distance running parallel said second cross-sectional distance.

11. The method of claim 1, further comprising the step of:

timing said step of controlling the charged particles along multiple axes with patient respiration to all of;

negative ion generation;

negative ion extraction and conversion to the charged particles;

acceleration of the charged particles;

extraction of the charged particles; and

delivery position of the charged particles to the tumor.

12. The method of claim 1, wherein said step of controlling said energy further comprises the step of:

using readings from a magnetic sensor, said magnetic sensor proximate a bending magnet in said synchrotron.

13. The method of claim 12, further comprising the step of:

stabilizing a magnetic field in said bending magnet using a feedback system using an input from said magnetic sensor by controlling a correction coil operating at less than ten percent of a power of a winding coil, both said correction coil and said winding coil wound around said bending magnet.

14. The method of claim 1, further comprising the step of:

controlling said energy using an accelerator system in said synchrotron, said accelerator system comprising;

a set of at least ten coils;

a set of at least ten wire loops; and

a set of at least ten microcircuits, each of said microcircuits integrated to one of said loops, wherein each of said loops completes at least one turn about at least one of said coils; and

using a radio-frequency synthesizer, sending a low voltage signal to each of said microcircuits, each of said microcircuits amplifying said low voltage signal yielding an acceleration voltage.