Apparatus and method for non-invasive measurement of a substance within a body
First Claim
1. A system for non-invasive measurement of a substance within a human body, comprising:
- a detector configured to sense radiation emitted or remitted from the human body;
an optical subsystem configured to focus the radiation on a sensitive area of the detector;
one or more temperature sensors attached to one or more of a plurality of elements of the optical subsystem and to the detector, the one or more temperature sensors being configured to measure the temperature of the one or more elements of the optical subsystem and the temperature of the detector; and
a microprocessor configured to reference a look-up table to compensate for perturbations in a substance concentration measurement due to the temperatures of the one or more elements of the optical subsystem and the temperature of the detector.
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Accused Products
Abstract
A system for non-invasive measurement of a substance, such as glucose, includes a detector configured to sense radiation and an optical subsystem configured to focus the radiation on a sensitive area of the detector. The system includes one or more temperature sensors attached to one or more of a plurality of elements of the optical subsystem and to the detector and two or more temperature sensors configured to measure two or more respective ambient temperatures. The one or more temperature sensors are configured to measure the temperature of the one or more elements of the optical subsystem and the temperature of the detector. A method of measuring a concentration includes detecting an infrared radiation value, measuring the temperature of the detector, one or more components of the optical system, and two or more ambient temperatures, and correlating the temperatures with calibration parameters to correct the detected infrared radiation value.
34 Citations
20 Claims
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1. A system for non-invasive measurement of a substance within a human body, comprising:
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a detector configured to sense radiation emitted or remitted from the human body; an optical subsystem configured to focus the radiation on a sensitive area of the detector; one or more temperature sensors attached to one or more of a plurality of elements of the optical subsystem and to the detector, the one or more temperature sensors being configured to measure the temperature of the one or more elements of the optical subsystem and the temperature of the detector; and a microprocessor configured to reference a look-up table to compensate for perturbations in a substance concentration measurement due to the temperatures of the one or more elements of the optical subsystem and the temperature of the detector. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9)
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10. Apparatus for non-invasive measurement of a substance within a body, the apparatus comprising:
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a detector for sensing radiation emitted or remitted from the body; optics configured to focus the radiation on a sensitive area of the detector; a baffle attached to and in thermal contact with the detector, the baffle being disposed to at least partially surround a detector sensitive area and configured to reduce the incidence of stray radiation on the detector sensitive area, wherein an interior surface of the baffle opposite the detector has a high reflectivity and low emissivity, the interior surface of the baffle being formed to reduce the incidence of radiation reflection or multi-reflection on the detector sensitive area; two or more temperature sensors configured to measure two or more respective ambient temperatures surrounding the apparatus, the detector, the optics, the baffle, or combinations thereof, the apparatus being configured to use the two or more surrounding ambient temperatures in measurement of the substance within the body; and one or more temperature sensors attached to one or more of a plurality of elements of the optics and to the detector, the one or more temperature sensors being configured to measure the temperature of the one or more elements of the optics and the temperature of the detector, wherein the temperature of the one or more of the plurality of optics elements and the temperature of the detector are matched with a set of predetermined compensation parameters stored in a look-up table for compensating for an effect on the non-invasive measurement of a concentration of the substance caused by the temperature of each of the one or more of the plurality of optics elements and the detector, the two or more surrounding ambient temperatures, and a temperature measured at a surface of the body. - View Dependent Claims (11, 12)
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13. A method comprising:
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using an apparatus including a detector and an optical system; detecting an infrared radiation value emitted by a human body in a wavelength range including at least one wavelength characteristic of a substance in the human body; measuring the temperature of the detector and one or more components of the optical system; correlating the temperatures of the detector and the one or more components of the optical system with a set of predetermined calibration parameters to correct the detected infrared radiation value for the effects of the emission of each of the detector and the one or more components of the optical system; and noninvasively measuring a concentration of the substance in the human body. - View Dependent Claims (14, 15, 16, 17, 18, 19, 20)
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Specification