Cardiopulmonary functional status assessment via metabolic response detection by implantable cardiac device

• US 8,903,491 B2
• Filed: 09/12/2013
• Issued: 12/02/2014
• Est. Priority Date: 08/12/2004
• Status: Expired due to Fees

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Hopper, Donald L., Wilkoff, Bruce, Morris, Richard
• Primary Examiner(s): Bertram, Eric D.
• Application Number:
  US14/025,513
• Publication Number:
  US 20140012345A1
• Time in Patent Office: 446 Days
• Field of Search: 607/19
• US Class Current: 607/19
• CPC Class Codes: A61N 1/365 controlled by a physiological parameter, e.g. heart potential evoked response A61N1/371
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/36542 controlled by body motion, e.g. acceleration
• CPC Class Codes: A61N 1/36585 controlled by two or more physical parameters
• CPC Class Codes: A61N 1/3702 Physiological parameters A61N1/365 takes precedence; evoked response A61N1/371

Abstract

An implantable cardiac device is configured and programmed to assess a patient'"'"'s cardiopulmonary function by evaluating the patient'"'"'s minute ventilation response. Such evaluation may be performed by computing a minute ventilation response slope, defined as the ratio of an incremental change in minute ventilation to an incremental change in measured activity level. The minute ventilation response slope may then be compared with a normal range to assess the patient'"'"'s functional status.

Claims

1. An implantable medical device, comprising:

a controller programmed to control the delivery of pacing pulses in accordance with a programmed pacing mode;

a minute ventilation sensor interfaced to the controller;

an activity level sensor interfaced to the controller for measuring a parameter related to a patient'"'"'s level of physical activity;

wherein the controller is programmed to construct a historical record of activity level versus minute ventilation, referred to as a minute ventilation response profile;

wherein the controller is further programmed to monitor a patient'"'"'s cardiopulmonary functional status by computing a minute ventilation response slope from the minute ventilation response profile, defined as the ratio of an incremental change in minute ventilation to an incremental change in measured activity level, and compare the minute ventilation response slope to a specified limit value; and

,

wherein the controller is further programmed to update the minute ventilation response profile by averaging a currently measured minute ventilation over an N second interval and associating the averaged minute ventilation with an activity level corresponding to an average of a currently measured activity level over the N second interval, wherein the minute ventilation response profile is updated only if activity level measurements taken over the N second interval meet a predefined stability criterion that involves a comparison of a statistic of the activity level measurements with a limit value.

2. The device of claim 1 wherein the minute ventilation response profile is a data structure containing a plurality of minute ventilation measurements, each minute ventilation measurement being associated with a discrete activity level.

3. The device of claim 2 wherein the controller is further programmed to adjust a rate-response factor used in rate-adaptive pacing upon detection of a change in the minute ventilation response slope to a specified extent.

4. The device of claim 3 wherein the controller is further programmed to adjust the rate-response to decrease the frequency of pacing upon detection that the minute ventilation response slope has improved to a specified extent.

5. The device of claim 1 wherein the statistic is a variance 4.

6. The device of claim 1 wherein the controller is programmed to set an alarm flag if the minute ventilation response slope is not within a normal range as defined by upper and lower limit values.

7. The device of claim 1 wherein the controller is programmed to adjust a lower rate limit interval for delivering pacing pulses upon detecting that the patient'"'"'s minute ventilation response slope has changed to a specified extent.

8. The device of claim 1 wherein the controller is further programmed to deliver pacing pulses in an atrial-triggered mode such that a ventricular pace is delivered upon expiration of an escape interval designated as the AV delay interval.

9. The device of claim 1 wherein the controller is further programmed to adjust the rate-response to increase the frequency of pacing upon detection that the minute ventilation response slope has worsened to a specified extent.

10. The device of claim 1 further comprising:

sensing/pacing channels for delivering cardiac resynchronization pacing in the form of biventricular pacing with a specified biventricular offset interval; and

,

wherein the controller is further programmed to adjust the biventricular offset interval upon detection of a change in the minute ventilation response slope to a specified extent.

11. A method for operating an implantable medical device, comprising:

programming a controller to deliver pacing pulses in accordance with a programmed pacing mode;

wherein the controller is interfaced to a minute ventilation sensor that measures a patient'"'"'s minute ventilation and to an activity level sensor that measures a parameter related to a patient'"'"'s level of physical activity;

programming the controller to;

construct a historical record of activity level versus minute ventilation, referred to as a minute ventilation response profile;

monitor a patient'"'"'s cardiopulmonary functional status by computing a minute ventilation response slope from the minute ventilation response profile, defined as the ratio of an incremental change in minute ventilation to an incremental change in measured activity level, and comparing the minute ventilation response slope to a specified limit value; and

,

update the minute ventilation response profile by averaging a currently measured minute ventilation over an N second interval and associating the averaged minute ventilation with an activity level corresponding to an average of a currently measured activity level over the N second interval, wherein the minute ventilation response profile is updated only if activity level measurements taken over the N second interval meet a predefined stability criterion that involves a comparison of a statistic of the activity level measurements with a limit value.

12. The method of claim 11 wherein the minute ventilation response profile is a data structure containing a plurality of minute ventilation measurements, each minute ventilation measurement being associated with a discrete activity level.

13. The method of claim 12 further comprising adjusting a rate-response factor used in rate-adaptive pacing upon detection of a change in the minute ventilation response slope to a specified extent.

14. The method of claim 13 further comprising adjusting the rate-response to decrease the frequency of pacing upon detection that the minute ventilation response slope has improved to a specified extent.

15. The device of claim 11 wherein the statistic is a variance.

16. The method of claim 11 further comprising setting an alarm flag if the minute ventilation response slope is not within a normal range as defined by upper and lower limit values.

17. The method of claim 11 further comprising adjusting a lower rate limit interval upon detecting that the patient'"'"'s minute ventilation response slope has changed to a specified extent.

18. The method of claim 11 further comprising delivering pacing pulses in an atrial-triggered mode such that a ventricular pace is delivered upon expiration of an escape interval designated as the AV delay interval.

19. The method of claim 11 further comprising adjusting the rate-response to increase the frequency of pacing upon detection that the minute ventilation response slope has worsened to a specified extent.

20. The method of claim 11 further comprising:

delivering cardiac resynchronization pacing in the form of biventricular pacing with a specified biventricular offset interval; and

,

adjusting the biventricular offset interval upon detection of a change in the minute ventilation response slope to a specified extent.