Method, system and apparatus for control of pancreatic beta cell function to improve glucose homeostasis and insulin production
First Claim
1. A method for treating a metabolic disease or disorder in a human subject suffering from said metabolic disease or disorder by inhibiting secretion of calcitonin gene-related peptide (CGRP) from one or more C-afferent sensory nerve fibers, comprising:
- applying, via a pulse generator in operable communication with an implantable lead, an electrical impulse to one or more C-afferent sensory nerve fibers innervating pancreatic beta cells in the subject, the electrical impulse configured to have a frequency ranging from 60 to 10,000 Hz and further configured to inhibit the secretion of CGRP from the one or more C-afferent sensory nerve fibers to treat the metabolic disease/disorder.
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Abstract
The present invention provides methods, systems and apparatuses for effecting excitation or inhibition of small sensory nerve fibers, such as C-afferent fibers, by electrical stimulation of nerves innervating the pancreas in diabetic subjects. In an aspect the methods are directed to effecting insulin production and for the treatment of diabetes. This invention includes a closed or open loop feedback control system in which biomarker levels are monitored in order to direct electrical stimulation. An implantable or external neural stimulation device is also provided.
33 Citations
41 Claims
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1. A method for treating a metabolic disease or disorder in a human subject suffering from said metabolic disease or disorder by inhibiting secretion of calcitonin gene-related peptide (CGRP) from one or more C-afferent sensory nerve fibers, comprising:
applying, via a pulse generator in operable communication with an implantable lead, an electrical impulse to one or more C-afferent sensory nerve fibers innervating pancreatic beta cells in the subject, the electrical impulse configured to have a frequency ranging from 60 to 10,000 Hz and further configured to inhibit the secretion of CGRP from the one or more C-afferent sensory nerve fibers to treat the metabolic disease/disorder. - View Dependent Claims (2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18)
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19. A system adapted for treating a metabolic disease or disorder in a human subject suffering form said metabolic disease or disorder by inhibiting secretion of CGRP from one or more C-afferent sensory nerve fibers, comprising:
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a power supply configured to generate an electrical impulse having a frequency of 60 Hz to 10,000 Hz; and an implantable lead configured to apply the electrical impulse configured to stimulate C-afferent sensory nerve fibers innervating pancreatic beta cells in a subject, wherein the electrical impulse is configured to inhibit a secretion of CGRP from said C-afferent sensory nerve fibers. - View Dependent Claims (20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36)
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37. An apparatus adapted for inhibiting secretion of CGRP from one or more C-afferent sensory nerve fibers comprising:
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a sensor configured to detect a biomarker level; a pulse generator configured to produce electrical stimulation as a function of the biomarker level; and an electrode lead or a multiple electrode array;
in which the pulse generator applies the electrical stimulation to the electrode lead or multiple electrode array; and
in which the electrode lead or multiple electrode array comprises an electrode to apply the electrical stimulation configured to stimulate C-afferent sensory nerve fibers innervating pancreatic beta cells in a subject, in which said electrical stimulation has a frequency of 60 Hz to 10,000 Hz and is configured to inhibit a secretion of from said C-afferent sensory nerve fibers. - View Dependent Claims (38, 39, 40, 41)
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Specification