Rejuvenation or preservation of germ cells

• US 8,903,660 B2
• Filed: 06/24/2010
• Issued: 12/02/2014
• Est. Priority Date: 06/24/2010
• Status: Expired due to Fees

• Current Assignee: Enterprise Science Fund, LLC (Intellectual Ventures LLC)
• Original Assignee: The Invention Science Fund I, L.L.C. (Intellectual Ventures LLC)
• Inventors: Hyde, Roderick A., Jung, Edward K. Y., Wood, Lowell L. Jr.
• Primary Examiner(s): Brusca, John S
• Application Number:
  US12/803,446
• Publication Number:
  US 20110321200A1
• Time in Patent Office: 1,622 Days
• Field of Search: None
• US Class Current: 702/19
• CPC Class Codes: A01N 1/0226 Physiologically active agents, i.e. substances affecting physiological processes of cells and tissue to be preserved, e.g. anti-oxidants or nutrients
• CPC Class Codes: A61K 35/54 Ovaries; Ova; Ovules; Embryos; Foetal cells; Germ cells
• CPC Class Codes: A61P 15/00 Drugs for genital or sexual disorders for disorders of sex hormones A61P5/24; Contraceptives

Abstract

Certain embodiments disclosed herein include, but are not limited to, at least one of compositions, methods, devices, systems, kits, or products regarding rejuvenation or preservation of germ cells or gametes. Certain embodiments disclosed herein include, but are not limited to, methods of modifying germ cells or gametes, or methods of administering modified germ cells or gametes to at least one biological tissue.

Claims

1. A computer-implemented method comprising:

regulating dispensing a composition from at least one delivery device to at least one reproductive cell by way of liposomal endocytosis or electroporation, the composition including at least one exogenous energy supplying factor of ATP, lactate, glucose, NADH, FADH₂, phosphocreatine, or creatine; and

wherein the at least one implantable delivery device includes at least one sensor configured to monitor the at least one energy supplying factor of the at least one reproductive cell.

2. The computer-implemented method of claim 1, wherein the at least one delivery device includes at least one implantable micro-electromechanical delivery device.

3. The computer-implemented method of claim 1, further including generating at least one output via a remote computing system.

4. The computer-implemented method of claim 3, wherein the generating at least one output includes generating at least one output to a user.

5. The computer-implemented method of claim 4, wherein the user includes at least one entity.

6. The computer-implemented method of claim 5, wherein the entity includes at least one person, or computer.

7. The computer-implemented method of claim 3, wherein the at least one output includes at least one graphical illustration of one or more of the composition, or at least one reproductive cell or substance associated with the at least one reproductive cell;

at least one property Of the at least one delivery device;

or at least one property of dispensing the at least one delivery device.

8. The computer-implemented method of claim 3, wherein the at least one output includes at least one protocol for making the composition based on one or more parameters of the at least one reproductive cell.

9. The computer-implemented method of claim 3, wherein the at least one output includes one or more parameters for selecting the at least one reproductive cell from other reproductive cells.

10. The computer-implemented method of claim 3, wherein the at least one output includes at least one protocol for dispensing the at least one composition to the at least one reproductive cell.

11. The computer-implemented method of claim 3, wherein the at least one output includes at least one output to a user readable display.

12. The computer-implemented method of claim 11, wherein the user readable display includes a human readable display.

13. The computer-implemented method of claim 11, wherein the user readable display includes one or more active displays.

14. The computer-implemented method of claim 11, wherein the user readable display includes one or more passive displays.

15. The computer-implemented method of claim 11, wherein the user readable display includes one or more of a numeric format, graphical format, or audio format.

16. The computer-implemented method of claim 1, wherein the dispensing the at least one composition to the at least one reproductive cell includes dispensing the at least one composition in response to one or more reproductive cell indicators.

17. The computer-implemented method of claim 1, further including receiving information related to one or more reproductive cell indicators prior to, during, or subsequent to administering the composition to the at least one reproductive cell.

18. The computer-implemented method of claim 17, wherein the receiving information related to one or more reproductive cell indicators includes information from at least one of an assay, image, or gross assessment of the at least one biological tissue prior to, during, or subsequent to administering the composition.

19. The computer-implemented method of claim 18, wherein the assay includes at least one technique including spectroscopy, microscopy, electrochemical detection, polynucleotide detection, histological examination, biopsy analysis, fluorescence resonance energy transfer, electron transfer, enzyme assay, electrical conductivity, isoelectric focusing, chromatography, immunoprecipitation, immunoseparation, aptamer binding, filtration, electrophoresis, immunoassay, or radioactive assay.

20. The computer-implemented method of claim 18, wherein the at least one image includes one or more images acquired by at least one of laser, holography, x-ray crystallography, optical coherence tomography, computer-assisted tomography scan, computed tomography, magnetic resonance imaging, positron-emission tomography scan, ultrasound, x-ray, electrical-impedance monitoring, microscopy, spectrometry, flow cytommetry, radioisotope imaging, thermal imaging, infrared visualization, multiphoton calcium-imaging, photography, or in silico generation.

21. The computer-implemented method of claim 1, wherein the at least one reproductive cell is at least partially located in at least one subject.

22. The computer-implemented method of claim 21, wherein the at least one subject includes at least one of an invertebrate or vertebrate animal.

23. The computer-implemented method of claim 21, wherein the at least one subject includes at least one of a reptile, mammal, amphibian, bird, or fish.

24. The computer-implemented method of claim 21, wherein the at least one subject includes at least one human.

25. The computer-implemented method of claim 21, wherein the at least one subject includes at least one plant.

26. The computer-implemented method of claim 1, wherein the delivery device further includes a RFID tag.

27. The computer-implemented method of claim 26, further including reading the RFID information and storing the information in a remote computing device.

28. The computer-implemented method of claim 1, wherein the sensor includes an oxygen sensor.

29. The computer-implemented method of claim 1, wherein the sensor is part of a micro-electromechanical or fluorimetry device.