Bio-impedance sensor and sensing method

• US 8,905,938 B2
• Filed: 05/24/2012
• Issued: 12/09/2014
• Est. Priority Date: 12/20/2005
• Status: Active Grant

• Current Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Original Assignee: Cardiac Pacemakers Incorporated (Boston Scientific Corporation)
• Inventors: Hatlestad, John D., Brockway, Marina, Dalal, Yousufali Husaini, Moon, Loell Boyce
• Primary Examiner(s): Hindenburg, Max
• Assistant Examiner(s): DANEGA, RENEE A
• Application Number:
  US13/479,967
• Publication Number:
  US 20120245475A1
• Time in Patent Office: 929 Days
• Field of Search: 600/484
• US Class Current: 600/484
• CPC Class Codes: A61B 5/0535 Impedance plethysmography for measuring blood flow A61B5/0295
• CPC Class Codes: A61B 5/0809 by impedance pneumography
• CPC Class Codes: A61B 5/7207 of noise induced by motion artifacts
• CPC Class Codes: A61N 1/36521 the parameter being derived from measurement of an electrical impedance
• CPC Class Codes: A61N 1/3684 for stimulating the heart at multiple sites of the ventricle or the atrium
• CPC Class Codes: A61N 1/36843 Bi-ventricular stimulation
• CPC Class Codes: A61N 1/39622 Pacing therapy

Abstract

Implantable medical devices and techniques are implemented that use bio-impedance to measure aspects of patient physiology. A signal separation method is performed at least in part in an implantable device. The method involves detecting a plurality of impedance signals using a plurality of implantable electrodes coupled to the implantable device. The method further involves separating one or more signals from the plurality of impedance signals using a signal separation technique, such as an algorithm-based separation technique.

Claims

1. A medical device, comprising:

a plurality of implantable electrodes configured for concurrent sensing of bio-impedance across multiple vectors to provide a plurality of impedance signals, the plurality of impedance signals comprising a primary impedance signal that includes a respiratory component and noise comprising a cardiac stroke component that corrupts the respiratory component; and

a processor coupled to the plurality of electrodes and configured to receive the plurality of impedance signals, the processor further configured to implement a signal separation technique on a combination of the plurality of impedance signals to separate a respiration signal from the plurality of impedance signals including the corrupting cardiac stroke component, the separated respiration signal characterized by the primary impedance signal substantially free of the corrupting cardiac stroke component.

2. The device of claim 1, further comprising communication circuitry coupled to the processor, the communication circuitry configured to transfer the separated respiration signal to a patient-external receiver.

3. The device of claim 1, wherein the processor is configured to form a linear combination of impedance signals that increases a signal-to-noise ratio for the separated respiration signal.

4. The device of claim 3, wherein the processor is configured to perform source separation when forming the linear combination of impedance signals.

5. The device of claim 1, wherein the processor is configured to perform adaptive noise cancellation to separate the respiration signal.

6. The device of claim 1, wherein:

the processor is configured to identify one or more additional separated signals with one or more signals of interest, the one or more signals of interest comprising a physiological signal; and

the physiological signal comprises a signal associated with one or more of respiration, cardiac activity, and a signal useful for detecting presence of thoracic fluid.

7. The device of claim 6, wherein the processor is configured to perform matching of a morphology of a separated signal with a morphology of a signal of interest.

8. The device of claim 6, wherein the processor is configured to perform matching of frequency content of a separated signal with frequency content of a signal of interest.

9. The device of claim 6, wherein the processor is configured to perform matching of timing of events within a separated signal with timing of events within a signal of interest.